Evidence map›Paper›PMID 41920224›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2026

Campylobacter jejuni strains isolated in Brazil have important virulence related genes and survive to different stress conditions.

Miliane Rodrigues Frazão, Amanda Aparecida Seribelli, Carolina Nogueira Gomes, Giovana do Nascimento Pereira, Guojie Cao, Marta Inês Cazentini Medeiros, Sheila da Silva Duque, Marc William Allard, Juliana Pfrimer Falcão

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Miliane Rodrigues FrazãoDepartment of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, FCFRP-USP, Avenida Do Café, S/N., Bloco S - Sala 41, Ribeirão Preto, SP, Brazil.
Amanda Aparecida SeribelliRibeirão Preto Medical School, University of São Paulo, FMRP-USP, Ribeirão Preto, SP, Brazil.
Carolina Nogueira GomesDepartment of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, FCFRP-USP, Avenida Do Café, S/N., Bloco S - Sala 41, Ribeirão Preto, SP, Brazil.
Giovana do Nascimento PereiraDepartment of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, FCFRP-USP, Avenida Do Café, S/N., Bloco S - Sala 41, Ribeirão Preto, SP, Brazil.
Guojie CaoDivision of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, USA.
Marta Inês Cazentini MedeirosAdolfo Lutz Institute of Ribeirão Preto, Ribeirão Preto, SP, Brazil.
Sheila da Silva DuqueOswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil.
Marc William AllardDivision of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, USA.
Juliana Pfrimer FalcãoDepartment of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, FCFRP-USP, Avenida Do Café, S/N., Bloco S - Sala 41, Ribeirão Preto, SP, Brazil. jufalcao@fcfrp.usp.br.ORCID http://orcid.org/0000-0002-1459-9355

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Campylobacter jejuni has been reported as the leading bacterial pathogen that causes foodborne gastroenteritis in humans in many countries. This study aimed to assess the survival of 46 C. jejuni strains isolated from food (14), humans (18), and animals (14) in Brazil from 1996–2016 under different stress conditions, evaluate their invasion and survival capacity in Caco-2 cells and U-937 macrophages and determine virulence using the Galleria mellonella model for 23 selected strains. Furthermore, this study aimed to analyze the frequency of virulence related genes using WGS data. All 46 C. jejuni studied survived to acid stress with survival rates ranging from 29 to 100%. All studied strains survived to incubation in BHI with a final concentration of 7.5% NaCl with survival rates ranging from 3 to 100%. All strains showed growth in the temperatures analyzed with survival rates ranging from 5 to 100% at 4ºC and from 50 to 100% at 37ºC. Only two strains survived after 1 h of incubation under oxidative stress. All strains studied showed the ability to invade Caco-2 cells and to survive in U-937 macrophages. Regarding virulence in G. mellonella, 64% of strains presented virulence equal to or greater than the reference strain. The majority of the virulence genes detected was related to different stress conditions, adhesion, motility, and invasion. In conclusion, the pathogenic potential of the C. jejuni strains studied was highlighted and the results obtained may suggest that more rigorous control measures of this pathogen in food, especially poultry products are needed.

Indexed as

Campylobacter InfectionsCampylobacter jejuniStress, PhysiologicalVirulence FactorsAnimalsBacterial ProteinsBrazilCaco-2 CellsFood MicrobiologyHumansMacrophagesMicrobial ViabilityMothsOxidative StressVirulenceBacterial ProteinsVirulence FactorsBrazilCampylobacter jejuniPathogenic potentialResistance to different stress conditionsVirulence related genesWhole genome sequencing

Identifiers

PMID41920224
PMCPMC13043972

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.