ArticleNano letters2026
Nanoscale Mapping Reveals Periodic Organization of Neutrophil Extracellular Trap Proteins.
Article in Nano letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Versatile and Scalable Reflective Micromirrors for Single-Objective Light Sheet Microscopy.Nano letters · 2026Article
- Versatile and Scalable Reflective Micromirrors for Single-Objective Light Sheet Microscopy.bioRxiv : the preprint server for biology · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neutrophils are essential cells of the innate immune system that release neutrophil extracellular traps (NETs) via NETosis. This specialized cell death pathway extrudes decondensed chromatin into the extracellular space. NET formation contributes to antimicrobial defense and coagulation, whereas dysregulated NETosis drives cancer, coagulopathy, and autoimmune diseases. Here we present a workflow combining optimized sample preparation, super-resolution imaging, and quantitative bioimage analysis to investigate the nanoscale organization of NETs. Our newly developed analysis tool, NanoNET, facilitates the NET protein binding pattern analysis. We identified specific NET proteins, including neutrophil elastase (NE) and proteinase 3 (PR3), that bind along DNA strands in a periodic fashion and are highly colocalized with nucleosomes, suggesting docking onto or around these structures. The workflow and analysis tools represent a significant methodological advance for studying protein distributions along NETs and filamentous structures in general. Understanding the NET filament organization is a critical step toward elucidating their formation and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.