Trial reportRevista da Associacao Medica Brasileira (1992)2026
Impact of low-flow desflurane versus sevoflurane anesthesia on thiol-disulfide homeostasis in adults undergoing elective thyroidectomy: a randomized controlled trial.
Trial report in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThiol-disulfide homeostasis is a marker of oxidative stress. The aim of the study was to compare the effects of low-flow desflurane and sevoflurane anesthesia on perioperative changes in thiol-disulfide balance in patients undergoing thyroidectomy.
methodsIn this randomized controlled trial, 50 ASA I-II patients were assigned to receive low-flow desflurane (n=25) or sevoflurane (n=25). Blood samples were collected before and after surgery. The primary outcomes were between-group comparisons of perioperative changes in total and native thiol levels. Secondary outcomes included changes in disulfide concentrations and thiol-disulfide ratios.
resultsFor the primary outcomes, the magnitude of reduction in total thiol (86.4±159.7 vs. 151.5±104.9 μmol/L; p=0.095) and native thiol (79.3±130.1 vs. 115.1±86.3 μmol/L; p=0.257) did not differ significantly between the desflurane and sevoflurane groups. For the secondary outcomes, disulfide levels significantly decreased in the sevoflurane group (67.5±19.9 vs. 48.4±18.1 μmol/L; p=0.001), whereas no significant change was observed in the desflurane group (60.2±23.2 vs. 52.5±34.5 μmol/L; p=0.300). Between-group comparisons of disulfide/total thiol, native thiol/total thiol, and disulfide/native thiol ratios revealed no significant differences.
conclusionLow-flow desflurane and sevoflurane anesthesia demonstrated similar effects on perioperative thiol-disulfide homeostasis in thyroidectomy patients.
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