ArticleEpidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil2026
Severe cases of hepatitis A: case series in Curitiba, Paraná, 2023-2024.
Article in Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDescribe the epidemiological profile of the hepatitis A outbreak in Curitiba, Paraná, between November 2023 and May 2024, with emphasis on the clinical and laboratory characterization of cases that progressed to death or liver transplantation.
methodsDescriptive case series study based on confirmed cases of hepatitis A. Severe cases, defined by death or liver transplantation, were identified via the Mortality Information System and Hospital Epidemiological Surveillance Centers. Clinical and laboratory data were obtained by reviewing medical records. Proportions, measures of central tendency, and dispersion were calculated.
resultsAmong the 281 confirmed cases, the majority were male (74.7%), with a median age of 29 years. Six people (2.1%) progressed to severe forms, of whom three received a diagnosis of fulminant hepatitis. The median age of the severe cases was 43 years, with a male predominance (5/6), and two were homeless individuals. Among the severe cases, five resulted in death, and one in a liver transplant. The most common symptoms and complications were jaundice, acute renal failure, and the need for mechanical ventilation (5/6). Laboratory results indicated hepatic dysfunction (median aspartate aminotransferase of 3,448 U/L; median international normalized ratio of 3) and renal dysfunction (median urea 52 mg/dL and creatinine 3 mg/dL). The median hospitalization length was 11 days.
conclusionIn this outbreak, there were cases requiring liver transplantation and progressing to death, demonstrating that, although generally self-limiting, the disease can present with a severe course. Timely response and targeted vaccination may be key strategies in outbreak scenarios.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.