Evidence map›Paper›PMID 41919667›Full record

SynthesisHuman vaccines & immunotherapeutics2026

Meta-analysis of the efficacy of palivizumab versus nirsevimab at preventing medically attended respiratory syncytial virus infections in non-hospitalized preterm infants.

John Fullarton, Bosco Paes, Nicola Waghorne, Ian Keary, Barry Rodgers-Gray, Xavier Carbonell-Estrany

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John FullartonScientific Services, Violicom Medical Limited, Aldermaston, UK.
Bosco PaesNeonatology, McMaster University, Hamilton, Ontario, Canada.
Nicola WaghorneScientific Services, Violicom Medical Limited, Aldermaston, UK.
Ian KearyScientific Services, Violicom Medical Limited, Aldermaston, UK.
Barry Rodgers-GrayScientific Services, Violicom Medical Limited, Aldermaston, UK.ORCID 0000-0003-0954-5587
Xavier Carbonell-EstranyNeonatology, Hospital Clinic, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Palivizumab has >27 y of proven effectiveness in the prevention of severe respiratory syncytial virus (RSV) infection in high-risk infants. However, there remains limited data on its efficacy at preventing medically attended, non-hospitalized RSV infections (MARI). A systematic literature review was undertaken to identify randomized, placebo-controlled studies of prophylactic interventions against MARI and RSV-related hospitalization in healthy infants born ≤35 weeks' gestational age (wGA). The findings informed a meta-analysis of three studies (N = 2,464) that found palivizumab significantly reduced MARI by 70.5% compared with placebo in 29-35 wGA infants, with broadly similar efficacy to nirsevimab.

Indexed as

Antibodies, Monoclonal, HumanizedAntiviral AgentsPalivizumabRespiratory Syncytial Virus InfectionsHumansInfantInfant, NewbornInfant, PrematureRandomized Controlled Trials as TopicTreatment OutcomeAntibodies, Monoclonal, HumanizedAntiviral AgentsPalivizumabimmunizationpalivizumabpretermRSVvaccine

Identifiers

PMID41919667
PMCPMC13048567

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.