Evidence map›Paper›PMID 41919211›Full record

ArticleRSC advances2026

Unveiling the reaction mechanism and the regioselectivity of Diels-Alder cycloadditions between 2-methoxy-3-thiophenylbutadiene and methyl vinyl ketone using topological tools.

Mohamed Chellegui, Sabir A Mohammed Salih, Lakhdar Benhamed, Haydar A Mohammad-Salimd, Ali Ben Ahmed

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohamed ChelleguiNamur Institute of Structured Matter, University of Namur Rue de Bruxelles, 61 Namur B-5000 Belgium.ORCID https://orcid.org/0009-0004-7818-8573
Sabir A Mohammed SalihUniversity of Zakho/college of science/ department of chemistry Algeria.
Lakhdar BenhamedLaboratory of Applied Thermodynamics and Molecular Modelling (LAT2M), Department of Chemistry, Faculty of Science, University of Tlemcen PB 119 Tlemcen 13000 Algeria.ORCID https://orcid.org/0000-0001-8520-6187
Haydar A Mohammad-SalimdDepartment of Chemistry, Faculty of Science, University of Zakho Zakho 42002 Kurdistan Region Iraq.ORCID https://orcid.org/0000-0002-9600-3446
Ali Ben AhmedLaboratory of Applied Physics, Department of Physics, Faculty of Sciences of Sfax, University of Sfax Sfax Tunisia.ORCID https://orcid.org/0000-0001-8560-2630

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The [4 + 2] Diels-Alder cycloaddition reaction between 2-methoxy-3-thiophenylbutadiene 1 and methyl vinyl ketone 2 has been studied at the density functional theory level using a panoply of tools to unravel the regioselectivity and the reaction mechanisms. From the analysis of the CDFT reactivity indices, 2 behaves as an electrophile, while 1 behaves as a nucleophile. This cycloaddition is characterized by a non-polar character as evaluated by a low value of the electrophilicity difference between the reactants as well as a low value of the global electron density transfer at the transition state. Futher, the bonding evolution theory shows that this reaction takes place

Identifiers

PMID41919211
PMCPMC13034432

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.