Evidence map›Paper›PMID 41919181›Full record

ArticleWorld journal of pediatric surgery2026

Targeted immune response gene expression profiles linked with necrosis and mortality in preterm infants with surgical necrotizing enterocolitis.

Parvesh Mohan Garg, Robin Riddick, Pengbo Zhang, Jeffrey Shenberger, Neha Varshney, David Sawaya, Padma Garg

Abstract read
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In one paragraph

Article in World journal of pediatric surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Parvesh Mohan GargDepartment of Pediatrics/Neonatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0001-5949-7304
Robin RiddickDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Pengbo ZhangDepartment of Pediatrics/Neonatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jeffrey ShenbergerPediatrics/Neonatology, Connecticut Children's Medical Center, Hartford, Connecticut, USA.
Neha VarshneyDeapartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
David SawayaDepartment of Pediatric Surgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Padma GargDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Background: We sought to determine changes in the expression of immune response-related genes occurring in surgical necrotizing enterocolitis (NEC) tissues from infants with necrosis severity and survival status. Methods: Targeted RNA sequencing of a select panel of 395 immune response genes was performed on RNA isolated from formalin-fixed, paraffin-embedded intestinal tissue samples ( Results: Thirty-five genes were differentially expressed (FDR-adjusted Conclusion: Severe necrosis and non-survival in NEC infants were associated with differential gene expression related to host defense, NK cell signaling and development, and apoptosis. Understanding the role of these pathways in severe NEC may guide the development of prognostic and treatment pathways.

Indexed as

Neonatology

Identifiers

PMID41919181
PMCPMC13034352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.