ArticleFrontiers in medicine2026
A model combining nocturnal baseline impedance, post-reflux swallow-induced peristaltic wave, and acid exposure time enhances prediction of proton pump inhibitor response for extraesophageal symptoms in a Chinese population.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Gastroesophageal reflux disease(GERD) with extraoesophageal symptoms tends to respond poorly to proton pump inhibitors (PPIs). Aims: This study aimed to evaluate the role of mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index in predicting PPIs response among GERD patients with extraoesophageal symptoms. Methods: We investigated the predictive significance of clinical, endoscopic, and pre-treatment 24-h impedance-pH monitoring data in determining PPIs response, evaluating both the individual and combined predictive capacities of MNBI and PSPW index. Results: A total of 92 Chinese patients were analyzed, revealing pathological MNBI ( Conclusion: MNBI and PSPW index serve as independent predictors of PPI response in GERD patients with extraesophageal symptoms, including those with normal AET. Importantly, their combined use significantly enhances predictive performance. MNBI remains a valuable predictor in patients with only extraesophageal symptoms. This study conducted a preliminary investigation into the predictive role of the combined MNBI-PSPW model in a Chinese population, highlighting the clinical importance of impedance parameter integration in managing extraesophageal GERD.
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