Trial reportFrontiers in medicine2026
Effect of preoperative warming combined with dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery: a randomized controlled trial.
Trial report in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: We evaluated whether preoperative warming combined with dexmedetomidine reduces postoperative delirium (POD) in older patients undergoing hip fracture surgery. Methods: This single-blind randomized trial (March-November 2021) enrolled 197 patients aged ≥50 years scheduled for hip fracture surgery. Participants were randomized to warming plus dexmedetomidine (WD), warming alone (W), or control (C). The primary outcome of this manuscript was POD incidence, assessed twice daily from postoperative day (POD) 1 to 3 using the 3D-CAM. Secondary outcomes included delirium days, intraoperative temperature, pain scores (days 1-3), MoCA (days 1 and 3), serum S100β, IL-6, TNF- α, cortisol, and perioperative adverse events. Results: Of the 174 randomized patients, 153 completed the study and were included in the final analysis. Postoperative delirium occurred in 49.1% of patients in the control group, 26% in the warming group, and 14% in the warming combined with dexmedetomidine group ( Conclusions: Preoperative warming combined with dexmedetomidine was associated with a lower incidence and shorter duration of POD in older patients undergoing hip fracture surgery. Clinical Trial Registration: Chinese Clinical Trial Registry (ChiCTR2100042142) http://www.chictr.org.cn/showproj.aspx?proj=62146.
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