Evidence map›Paper›PMID 41919128›Full record

ReviewIMA fungus2026

Interconnected worlds: a comprehensive review of fungal defenses, antimicrobial resistance, and their evolutionary dynamics.

Yuan Sui, Mir Muhammad Nizamani, Entaj Tarafder, Hai-Li Zhang, Qian Zhang, Krishnendu Acharya, Jit Sarkar, Ghulam Muhae-Ud-Din, Yong Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in IMA fungus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuan SuiChongqing Key Laboratory for Germplasm Innovation of Special Aromatic Spice Plants, College of Smart Agriculture/Institute of Special Plants, Chongqing University of Arts and Sciences, Yongchuan, Chongqing 402160, China Centre of Advanced Study, University of Calcutta Kolkata India https://ror.org/01e7v7w47.ORCID https://orcid.org/0000-0002-3034-0642
Mir Muhammad NizamaniDepartment of Plant Pathology, College of Agriculture, Guizhou University, Guiyang 550025, China Institute of Special Plants, Chongqing University of Arts and Sciences Chongqing China https://ror.org/01rcvq140.ORCID https://orcid.org/0000-0002-8709-9212
Entaj TarafderDepartment of Plant Pathology, College of Agriculture, Guizhou University, Guiyang 550025, China Institute of Special Plants, Chongqing University of Arts and Sciences Chongqing China https://ror.org/01rcvq140.ORCID https://orcid.org/0000-0002-3680-3433
Hai-Li ZhangSanya Nanfan Research Institute of Hainan University, Hainan Yazhou Bay Seed Laboratory, Hainan University, Sanya 572025, China College of Agriculture, Guizhou University Guiyang China https://ror.org/02wmsc916.
Qian ZhangDepartment of Plant Pathology, College of Agriculture, Guizhou University, Guiyang 550025, China Institute of Special Plants, Chongqing University of Arts and Sciences Chongqing China https://ror.org/01rcvq140.
Krishnendu AcharyaMolecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, Centre of Advanced Study, University of Calcutta, Kolkata 700019, India Hainan Yazhou Bay Seed Laboratory, Hainan University Sanya China https://ror.org/03q648j11.
Jit SarkarMolecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, Centre of Advanced Study, University of Calcutta, Kolkata 700019, India Hainan Yazhou Bay Seed Laboratory, Hainan University Sanya China https://ror.org/03q648j11.
Ghulam Muhae-Ud-DinDepartment of Plant Pathology, College of Agriculture, Guizhou University, Guiyang 550025, China Institute of Special Plants, Chongqing University of Arts and Sciences Chongqing China https://ror.org/01rcvq140.
Yong WangDepartment of Plant Pathology, College of Agriculture, Guizhou University, Guiyang 550025, China Institute of Special Plants, Chongqing University of Arts and Sciences Chongqing China https://ror.org/01rcvq140.ORCID https://orcid.org/0000-0003-3831-2117

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal defense mechanisms and antimicrobial resistance to therapeutic remedies represent a complex and evolving challenge. This review explores the multifaceted processes that determine fungal resistance and covers cellular, evolutionary, and global aspects. Key factors, such as cell wall integrity, efflux pumps, and adaptive responses, are examined, along with interdisciplinary analytical techniques used to elucidate defense mechanisms. Evolutionary drivers, including natural selection and horizontal gene transfer, are also discussed. The review emphasizes the importance of global coordination, personalized medicine, ethical principles, and sustainable practices in both healthcare and agriculture to address the growing problem of antimicrobial resistance to therapeutic drugs. It synthesizes existing literature and offers recommendations for future research and initiatives designed to support a global effort capable of proactively addressing antimicrobial resistance and overcoming fungal defense mechanisms, thereby mitigating their impact on human health and food production.

Indexed as

Adaptive responsescell wall integrityefflux pumpsenzymatic breakdownhorizontal gene transferinterdisciplinary collaboration

Identifiers

PMID41919128
PMCPMC13034067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.