Evidence map›Paper›PMID 41919002›Full record

ArticleEuropean journal of anaesthesiology and intensive care2026

Effects of hyperoxia on systolic and diastolic function assessed by strain analysis in patients with coronary artery disease during general anaesthesia.

Jan O Friess, Timo Laederach, Gabriele M Milani, Levis Anja, Sandra Terbeck, Markus Huber, Daniel Gerber, Gabor Erdoes, Florian S Schoenhoff, Raouf Madhkour and 2 more

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of anaesthesiology and intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04424433 (Myocardial Strain Analysis in Patients With Coronary Artery Disease at Hyperoxia and Normoxaemia Prior to Coronary Artery Bypass Graft Surgery - a Randomized Crossover Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04424433 nacompletednot on this map

Myocardial Strain Analysis in Patients With Coronary Artery Disease at Hyperoxia and Normoxaemia Prior to Coronary Artery Bypass Graft Surgery - a Randomized Crossover Study

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2020 to 2021Enrolled106ConditionsCoronary Artery Disease, AnesthesiaArmsOxygen
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jan O FriessFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Timo LaederachFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Gabriele M MilaniFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Levis AnjaFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Sandra TerbeckFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Markus HuberFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Daniel GerberFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Gabor ErdoesFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Florian S SchoenhoffFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Raouf MadhkourFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Kady FischerFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).
Dominik P GuenschFrom the Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (JOF, TL, GMM, AL, ST, MH, DG, GE, KF, DPG), Department of Cardiac Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (FSS), Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (RM).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac complications are a source of perioperative morbidity, but the impact of perioperative supplemental oxygen -a coronary vasoconstrictor- on the myocardium remains unclear.

objectiveTo determine the impact of supplemental oxygen on myocardial function in patients with coronary artery disease during general anaesthesia by 2D echocardiography. We hypothesised that 2D global systolic circumferential strain (GCS) worsens under hyperoxia.

designThis is a secondary analysis of a prospective randomised cross-over trial.

settingSingle tertiary centre. PATIENTS: Datasets from 99 patients undergoing elective coronary artery bypass surgery were analysed.

interventionDuring general anaesthesia, patients were exposed to normoxaemic and hyperoxic inspired oxygen fractions.

main outcome measuresTransoesophageal echocardiography cines were analysed in each state primarily for changes in 2D GCS. Secondarily systolic parameters such as 2D global systolic longitudinal strain (GLS), ejection fraction (EF) and diastolic parameters were analysed.

resultsGCS worsened under hyperoxia compared with normoxaemia (25.2% (26.6 to 23.8) vs. 26.1% (27.5 to 24.7),

conclusionsIn patients with coronary artery disease, mean GCS deteriorated with hyperoxia under general anaesthesia. Furthermore, circumferential strain based diastolic markers delineated a global and regional effect of hyperoxia on myocardial function. In the light of heterogeneous changes in systolic function with hyperoxia in individual patients, EF, GLS and GCS at normoxaemia may guide the utility of hyperoxia in patients with coronary artery disease undergoing general anaesthesia and as such may help to titrate supplemental oxygen in the individual patient.

trial registrationNCT04424433.

Identifiers

PMID41919002
PMCPMC13034905

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