Evidence map›Paper›PMID 41918961›Full record

ArticleFrontiers in allergy2026

Multi-omics insights into dietary zinc-mediated reprogramming of the gut-nasal ecosystem in allergic rhinitis.

Shiqi Yan, Zhijuan Zhang, Chunyan Xia, Peng Liu, Junbai Ma, Jian Liu, Tong Wu, Hao Wang, Ruixia Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shiqi YanThe Second Clinical Medical College, the First People's Hospital of Yinchuan, Ningxia Medical University, Yinchuan, China.
Zhijuan ZhangThe Second Clinical Medical College, the First People's Hospital of Yinchuan, Ningxia Medical University, Yinchuan, China.
Chunyan XiaDepartment of Laboratory Medicine, the First People's Hospital of Yinchuan, Yinchuan, China.
Peng LiuThe Second Clinical Medical College, the First People's Hospital of Yinchuan, Ningxia Medical University, Yinchuan, China.
Junbai MaNingxia Key Laboratory of Infection and Immunity, Department of Pathogenic Biology and Medical Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Jian LiuNingxia Key Laboratory of Infection and Immunity, Department of Pathogenic Biology and Medical Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Tong WuOtolaryngology Head and Neck Surgery Hospital, the First People's Hospital of Yinchuan, the Second Clinical Medical College, Ningxia Medical University, Yinchuan, China.
Hao WangNingxia Key Laboratory of Infection and Immunity, Department of Pathogenic Biology and Medical Immunology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China.
Ruixia MaThe Second Clinical Medical College, the First People's Hospital of Yinchuan, Ningxia Medical University, Yinchuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Allergic rhinitis (AR) represents a prevalent kind of allergic disorders. Increasing evidence has revealed the critical role of gut microbiota dysbiosis in its onset and progression. The gut-nasal axis connecting the immune system and intestinal microecology offers a novel strategy for AR intervention. Methods: This study employed a multi-omics approach to systematically investigate the therapeutic effects and underlying mechanisms of dietary Zinc (Zn) supplementation at a series of concentrations on AR. Results: The results indicated that Zn may exert alleviated AR in rats, especially at a dose of 150 ppm. Mechanistically, we found the effectiveness of Zn may attributed to inhibiting inflammation, restoring gut microbiota balance, enhancing microbial metabolite-short-chain fatty acids (SCFAs) production, and regulating the nasal mucosa metabolism. Discussion: Collectively, our study indicate that dietary Zn intervention ameliorates AR in rats via gut-nasal axis, which may potentially provide a novel therapeutic treatment for the control of the disease.

Indexed as

allergic rhinitisgut microbiotagut-nasal axisinflammationshort-chain fatty acidszinc

Identifiers

PMID41918961
PMCPMC13033786

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.