Evidence map›Paper›PMID 41918945›Full record

ArticleClinical psychological science : a journal of the Association for Psychological Science2026

Distinct Event-Related-Potential Biomarkers of Broad Versus Specific Dimensions of the Hierarchical Taxonomy of Psychopathology Externalizing Spectrum.

Christopher J Patrick, Pablo Ribes-Guardiola, Bruce D Bartholow, Alexander M Kallen, Emily R Perkins, Robert F Krueger, Colin G DeYoung, Roman Kotov, Rita Pasion, Sylia Wilson and 24 more

Abstract read
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In one paragraph

Article in Clinical psychological science : a journal of the Association for Psychological Science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Christopher J PatrickDepartment of Psychology, Florida State University, Tallahassee, FL, USA.
Pablo Ribes-GuardiolaDepartment of Basic Psychology, University of Valencia, Valencia, Spain.
Bruce D BartholowDepartment of Psychology, University of Iowa, Iowa City, IA, USA.
Alexander M KallenDepartment of Psychology, Florida State University, Tallahassee, FL, USA.
Emily R PerkinsDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, USA.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Colin G DeYoungDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Roman KotovDepartment of Psychiatry, Stony Brook University, Stony Brook, NY, USA.
Rita PasionLaboratory of Neuropsychophysiology, Faculty of Psychology and Educational Sciences, University of Porto, Porto, Portugal.
Sylia WilsonDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
James R YanceyRocky Mountain Mental Illness Research, Education and Clinical Center, Department of Veterans Affairs, Salt Lake City, UT, USA.
Sarah J BrislinRutgers Center for Addiction Research, Department of Psychiatry, Rutgers University, Piscataway, NJ, USA.
Sally L ColeDepartment of Psychology, Florida State University, Tallahassee, FL, USA.
David C CiceroDepartment of Psychology, University of North Texas, Denton, TX, USA.
Christopher ConwayDepartment of Psychology, Fordham University, Bronx, NY, USA.
Miriam K ForbesDepartment of Psychology, Macquarie University, Sydney, NSW, Australia.
Jeremy HarperDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Brian M HicksDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Christopher J HopwoodDepartment of Psychology, University of Zurich, Zurich, Switzerland.
William G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Katherine G JonasDepartment of Psychology, Stony Brook University, Stony Brook, NY, USA.
Antonia KaczkurkinDepartment of Psychology, Vanderbilt University, Nashville, TN, USA.
Robert D LatzmanTakeda Pharmaceutical Company Limited, Cambridge, Massachusetts, USA.
Kristian E MarkonDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Elizabeth A MartinDepartment of Psychological Science, University of California-Irvine, Irvine, CA, USA.
Giorgia MicheliniSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, UK.
Lindsay D NelsonDepartments of Neurosurgery & Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
Jonathan SchaeferDepartment of Psychology, Vanderbilt University, Nashville, TN, USA.
Martin SellbomSchool of Psychological Sciences, Monash University, Melbourne, VIC, Australia.
Noah C VenablesDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Irwin D WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.
Aidan G C WrightDepartment of Psychology and Eisenberg Family Depression Center, University of Michigan, Ann Arbor, MI, USA.
David H ZaldCenter for Advanced Human Brain Imaging Research, Department of Psychiatry, Rutgers University, Piscataway, NJ, USA.
Keanan J JoynerDepartment of Psychology, University of California-Berkeley, Berkeley, CA, USA.

Funding

U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
Project 6: Individual Differences in the Motivational Substrates (pg 275)P50MH072850 · NIMH · UNIVERSITY OF FLORIDA · PI LANG, PETER J · 2005 to 2009
$8.8M
Determining the Contributions of Four AARDoC Functional Domains to the Etiology of Heavy Drinking and AUD Symptoms: A Prospective, Multimodal ApproachR01AA030728 · NIAAA · UNIVERSITY OF IOWA · PI BRUCE D BARTHOLOW · 2023 to 2026
$2.9M
A rigorous test of dual process model predictions for problematic alcohol involvementR01AA030914 · NIAAA · UNIVERSITY OF IOWA · PI BRUCE D BARTHOLOW, DENIS M MCCARTHY · 2023 to 2026
$2.7M
Trait Fear and Disinhibition in Impulse Control DisordersRC1MH089727 · NIMH · FLORIDA STATE UNIVERSITY · PI PATRICK, CHRISTOPHER JOHN · 2009 to 2010
$942k
NIAAA NIH HHS R01 AA030728NIAAA NIH HHS R01 AA030914NIA NIH HHS U19 AG051426NIMH NIH HHS P50 MH072850NIMH NIH HHS RC1 MH089727
6 · The paper itself

Abstract

The Hierarchical Taxonomy of Psychopathology (HiTOP) provides a dimensional framework for connecting psychological disorders to neural systems/processes. We examined how neurophysiological measures of cognitive-attentional (oddball P300) and perceptual-emotional processing (fear-face N170/P200) relate to dimensions of the HiTOP externalizing spectrum. Employing 666 community participants, we fit a model in which antagonistic externalizing and substance problems subfactors, defined via symptom and questionnaire-scale measures, loaded with a disinhibitory trait scale onto a higher-order externalizing factor. Hierarchical regression was used to evaluate how much observed relations of each neural measure with the two subfactors reflected their unique variance versus their covariance (reflected in the general factor). P300's relations were fully accounted for by the general factor, suggesting that impaired cognitive processing characterizes broad risk for externalizing problems. Neural indicators of sensitivity to others' distress (N170, P200) were uniquely related to antagonistic externalizing. Findings highlight the HiTOP framework's potential to advance biobehavioral understanding of psychopathology.

Indexed as

antagonismevent-related potentials (ERPs)externalizingHiTOPsubstance use

Identifiers

PMID41918945
PMCPMC13035350

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.