Evidence map›Paper›PMID 41918944›Full record

ArticleFrontiers in medicine2025

Acyl-CoA synthetase long-chain family member 4-A novel prognostic marker in cutaneous melanoma.

Soumya Paria, Rebecca Lapides, Babak Saravi, Anjali Rajagopal, Alina M Torrez, Peter Kölblinger, Michael Wang-Evers, Dieter Manstein, Alexander A Navarini, Peter Lazar and 5 more

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Soumya Paria *School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, United Kingdom.
Rebecca Lapides *The Robert Larner, M.D. College of Medicine at the University of Vermont, Burlington, VT, United States.
Babak SaraviDepartment of Oral, Maxillofacial and Facial Plastic Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Anjali RajagopalDepartment of Internal Medicine, University of Connecticut, Farmington, CT, United States.
Alina M TorrezDepartment of Dermatology, University Hospital of Basel, Basel, Switzerland.
Peter KölblingerDepartment of Dermatology and Allergology, Paracelsus Medica University, Salzburg, Austria.
Michael Wang-EversCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Dieter MansteinCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Alexander A NavariniDepartment of Dermatology, University Hospital of Basel, Basel, Switzerland.
Peter LazarDepartment of Oral and Maxillofacial Surgery, Medical Center, University of Szeged, Szeged, Hungary.
Lajos V KeményDepartment of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Grzegorz SarekDepartment of Dermatology, University Hospital of Basel, Basel, Switzerland.
Kaustubh AdhikariSchool of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, United Kingdom.
István B NémethDepartment of Dermatology and Allergology, Szent-Györgyi Albert Medical School, University of Szeged, Szeged, Hungary.
Elisabeth RoiderCutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. Acyl coenzyme A (Acyl-CoA) synthetase long-chain family member 4 (ACSL4) promotes ferroptosis by enriching cellular membranes with polyunsaturated fatty acids, yet its prognostic relevance in melanoma remains unclear. We conducted a retrospective analysis of 63 patients with melanoma to evaluate associations between ACSL4 expression and overall survival (OS), metastasis-free survival (MFS), and disease-free survival (DFS). Correlation analyses and Cox proportional hazards (CoxPH) models were used to identify prognostic factors, and immune cell infiltration was assessed in tumor samples. Higher ACSL4 expression was consistently associated with improved OS, MFS, and DFS in cutaneous melanoma. ACSL4 levels also correlated with greater immune cell infiltration within the tumor microenvironment. Notably, metastatic melanoma cases exhibited higher ACSL4 expression than non-metastatic cases; however, within cutaneous melanoma, elevated ACSL4 remained linked to more favorable survival outcomes. Together, these findings position ACSL4 as a promising prognostic biomarker in melanoma and suggest a potential connection between ferroptosis biology and antitumor immunity. While the study is retrospective and correlative, it provides a strong rationale for prospective validation and mechanistic studies to test whether modulating ACSL4-driven ferroptosis can improve clinical outcomes.

Indexed as

ACSL4cutaneous melanomaferroptosisimmune cell infiltrationmetastatic melanomaprognostic markersurvival analysis

Identifiers

PMID41918944
PMCPMC13035052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.