Trial reportFrontiers in cellular and infection microbiology2026
Effects of dual-wavelength laser combined with periodontal flap surgery on periodontal parameters and inflammatory factors in patients with periodontic-endodontic lesions.
Trial report in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Objective: This study investigated the clinical effectiveness of dual-wavelength laser with periodontal flap surgery in managing periodontic-endodontic lesions (PEL) and its impact on periodontal parameters and inflammatory markers. Methods: A total of 106 PEL patients were randomly assigned to a study group or a control group (53 each). All patients first received root canal treatment. The control group underwent conventional periodontal flap surgery, whereas the study group received adjunctive dual-wavelength laser treatment (Nd: YAG for root canal disinfection and Er: YAG for periodontal pocket debridement). Pain visual analogue scale (VAS) scores were recorded prior to treatment and at 1 and 7 days postoperatively. Periodontal parameters, gingival crevicular fluid (GCF) and serum inflammatory markers, and bacterial infection/clearance rates were assessed at baseline and 3 months post-treatment. Clinical efficacy and incidences of tooth mobility, periodontitis recurrence, and percussion pain were evaluated at 6 months. Results: Ninety-nine patients completed follow-up (48 in the study group and 51 in the control group). On postoperative day 1, VAS scores increased in both groups but were significantly lower in the study group ( Conclusion: Dual-wavelength laser adjunctive therapy enhances the clinical efficacy of periodontal flap surgery in PEL, significantly improving periodontal healing, reducing inflammation, and promoting bacterial clearance.
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