ArticleFrontiers in chemistry2026
Synthesis and antimicrobial activity of sulfonyl-imidazole linked fused isoxazolo[3,4-b][1,2,3]triazolo[4,5-d]pyridines:PEG-400 mediated one-pot reaction under ultrasonic irradiation.
Article in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Silver-based N-heterocyclic carbene (NHC) complexes as emerging strategies against antimicrobial resistance.Archives of microbiology · 2026Review
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4 authors.
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Abstract
Introduction: The rapid emergence of methicillin-resistant and vancomycin-resistant Methods: In this study, a novel series of sulfonyl-imidazole-linked fused isoxazolo[3,4-b][1,2,3]triazolo[4,5-d]pyridine derivatives (6a-6o) was synthesized using a PEG-400-mediated, ultrasound-assisted one-pot Cu(I)-catalysed strategy under environmentally benign conditions. The synthesized compounds were evaluated for antibacterial activity against MSSA, MRSA, and VRSA strains, along with antibiofilm activity, hemolytic potential using mouse erythrocytes, and cytotoxicity in RAW 264.7, THP-1, and BoMac cells. Immunomodulatory effects were assessed through cytokine induction studies. Results: Several derivatives exhibited potent antibacterial activity, with compound 6k emerging as the most active candidate, displaying MIC values of 1.56-3.12 μg/mL and outperforming the reference drug dicloxacillin. Selected compounds also showed significant antibiofilm activity against resistant Discussion: Overall, compound 6k was identified as a promising lead with potent antibacterial, antibiofilm, and immunomodulatory properties, combined with a favourable safety profile, warranting further preclinical development against drug-resistant
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