ArticleFrontiers in aging neuroscience2026
Effects of aerobic exercise and computer-based cognitive training on cognition, functional independence, quality of life, and salivary cortisol levels in older adults with mild cognitive impairment: a randomized trial.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Mild Cognitive Impairment (MCI) represents an intermediate stage between normal aging and dementia, characterized by measurable cognitive decline without significant loss of functional independence. Non-pharmacological interventions, particularly aerobic exercise and cognitive training, have demonstrated potential benefits; however, their combined effects and underlying neurobiological mechanisms remain inadequately explored. Objective: To investigate the effects of aerobic exercise combined with computer-based cognitive training on cognitive function, functional independence, health-related quality of life, and salivary cortisol levels in older adults with MCI. Methods: This assessor-blinded, two-arm randomized controlled trial included 60 older adults (60-85 years) diagnosed with MCI. Participants were randomized to either an intervention group receiving aerobic exercise plus computer-based cognitive training ( Results: Both groups demonstrated significant within-group improvements in cognitive function, functional independence, quality of life, and cortisol levels over time ( Conclusion: Combining aerobic exercise with cognitive training improves clinical outcomes in older adults with MCI and may influence stress-related neurobiological pathways. This multimodal approach represents a promising, non-pharmacological strategy for mitigating age-related cognitive decline.
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