SynthesisFrontiers in microbiology2026
Berberine-gut microbiota interactions based on CiteSpace: current research status and hotspots.
Synthesis in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Research trends in cytokine regulation of immunotherapy in non-small cell lung cancer: a bibliometric and BERTopic analysis from 2015 to 2025.Journal of thoracic disease · 2026Article
- Berberine as a multitarget modulator of metabolic inflammation: molecular mechanisms, circadian regulation, and translational perspectives.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The gut microbiota modulates host metabolic and immune homeostasis through host-microbiota interactions and microbial metabolites. Berberine (BBR), the primary active constituent of Methods: Therefore, we conducted a bibliometric analysis of 426 articles retrieved from the Web of Science Core Collection (WOSCC) and the China National Knowledge Infrastructure (CNKI) database (January 1, 2005-January 31, 2025) using CiteSpace. Analyses included publication trends, country/author collaboration networks, keyword co-occurrence and burst detection, and document co-citation analysis. Results: The results revealed a steady increase in annual publications, with China contributing the majority of studies. Author collaboration networks indicated limited integration among research groups. Keyword analysis identified key research clusters such as diabetes, inflammation, bile acid metabolism, and colorectal cancer. Chinese studies placed greater emphasis on disease applications, whereas English-language articles tended to focus on mechanistic insights. Emerging research hotspots include depression, fecal microbiota transplantation, bile acids, and ulcerative colitis. Co-citation analysis highlighted two foundational themes: microbial metabolites and metabolic-immune crosstalk. Discussion: This bibliometric study systematically outlines the research landscape of berberine-gut microbiota interactions, highlighting emerging frontiers such as neuro-microbial crosstalk, fecal microbiota transplantation (FMT) -based combination therapies, and metabolic-immune mechanisms. The findings provide valuable references for identifying research trends, fostering collaboration, and guiding future investigations in this field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.