ArticleJPEN. Journal of parenteral and enteral nutrition2026
Association between prescribed parenteral energy doses and the composite of clinical adverse events in adult patients after gastrointestinal cancer surgery: A retrospective cohort study.
Article in JPEN. Journal of parenteral and enteral nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Reply to: "Amino acid strategy in early postoperative parenteral nutrition".JPEN. Journal of parenteral and enteral nutrition · 2026Article
- Amino acid strategy in early postoperative parenteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2026Article
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4 authors.
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Abstract
backgroundWe aimed to compare the impact of prescribed parenteral energy on clinical outcomes in patients who exclusively received parenteral nutrition after gastrointestinal cancer surgery.
methodsWe identified patients who exclusively received parenteral nutrition for ≥7 days after surgery using a medical claims database. Based on the mean parenteral energy doses during postoperative days 1-7, patients were divided into restricted-energy (5-10 kcal/kg/day), low-energy (10-20 kcal/kg/day), and standard-energy (20-30 kcal/kg/day) groups. The primary outcome was a composite of clinical adverse events, and secondary outcomes included in-hospital mortality, postoperative complications, declines in activities of daily living, hospital readmission, and length of hospital stay (LOS). Multivariable logistic and multiple regression analyses were employed using the restricted-energy group as the reference.
resultsOf 18,294 eligible patients, 6727, 9760, and 1807 were classified into the restricted-, low-, and standard-energy groups, respectively. The adjusted odds ratio (95% confidence interval) for the composite outcome was 1.062 (0.972-1.161; P = 0.18) in the low-energy group and 1.093 (0.942-1.267; P = 0.24) in the standard-energy group. For in-hospital mortality, the adjusted odds ratio was 1.060 (1.057-1.062; P < 0.001) in the low-energy group and 1.281 (1.275-1.287; P < 0.001) in the standard-energy group. The adjusted regression coefficient (95% confidence interval) for LOS was 2.0 (0.7-3.3; P = 0.004) in the low-energy group and 3.2 (1.0-5.5; P = 0.005) in the standard-energy group. No significant differences were observed in other outcomes.
conclusionEarly postoperative higher energy doses were associated with increased in-hospital mortality and LOS.
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