Evidence map›Paper›PMID 41918203›Full record

ArticleCurrent drug metabolism2026

Deciphering the Impact of Protein Corona on Biological Fate of Nanomedicine-loaded Microneedles.

Junli Zhu, Wenhao Wang, Zhengwei Huang

Abstract readEditorial
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In one paragraph

Article in Current drug metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Junli ZhuState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511443, P.R. China.
Wenhao WangSchool of Pharmaceutical Science, Sun Yat-Sen University, Guangzhou, 510006, P.R. China.
Zhengwei HuangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou, 511443, P.R. China.

Funding

Foundation of Key Laboratory for Magnetic Medicine of Shaanxi Province 2025MMKF-01Science and Technology Project in Guangzhou 202102070001
6 · The paper itself

Abstract

Due to adsorption of proteins, abundant protein molecules quickly bind to the nanoparticles' (NPs) surface when they enter the bloodstream, forming a "protein corona." The protein corona leads to rapid clearance of NPs, thereby impeding efficient drug delivery. Notably, microneedles (MNs) can reduce protein corona formation by altering the route of drug entry and confining the drug within the local tissue microenvironment. This article outlines the relationship between drug-loaded MNs and the protein corona and proposes strategies to suppress its formation. Furthermore, it underscores that the synergy between microneedles and stealth nanocarriers can minimize the detrimental effects associated with protein corona formation.

Indexed as

Drug Delivery SystemsNanoparticlesProtein CoronaAnimalsHumansMicroneedle Drug DeliveryNanomedicineProtein Coronabloodstreamdermal interstitial fluidMicroneedlesnanomedicineprotein coronastealthy effect

Identifiers

PMID41918203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.