ArticleJournal of breast cancer2026
Germline Mutations Related to Complete Remission After Neoadjuvant Chemotherapy in Patients With Triple-negative Breast Cancer.
Article in Journal of breast cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTriple-negative breast cancer (TNBC) is a frequent phenotype of
methodsA total of 148 women with TNBC were recruited from December 2015 to November 2018, as part of a sub-analysis based on the PEARLY trial data. Of them, 103 patients received neoadjuvant chemotherapy (NCT). The targeted genes related to hereditary cancers were sequenced using the 65-gene germline next-generation sequencing (gNGS) panel pathogenic and likely pathogenic variants (P&LPs) were determined by Sanger sequencing. We examined the occurrence of pathologic complete remission (ypCR) in patients with P&LPs.
resultsThe patients' median age was 47 years (range, 27-69 years). Twenty (13.7%) of 148 patients had P&LP in six genes, including
conclusionGermline P&LP mutations in TNBC patients can be detected by gNGS. This panel test can identify
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