Evidence map›Paper›PMID 41918137›Full record

ArticleEye and vision (London, England)2026

Variation in corneal biomechanical properties following continuous cross-linking treatment.

ChenHao Zhao, XinYu Yao, YeWei Zhao, HongJiang Wu, JiaHui Zong, XuanYa Tong, Daniela Oehring, Lan Yang, XiaoFei Zhou, Ying Li and 7 more

Abstract read
In one paragraph

Article in Eye and vision (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

ChenHao Zhao *National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
XinYu Yao *National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
YeWei ZhaoNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
HongJiang WuNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
JiaHui ZongNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
XuanYa TongNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
Daniela OehringSchool of Health Professions, University of Plymouth, Plymouth, PL4 8AA, UK.ORCID http://orcid.org/0000-0003-2954-0548
Lan YangNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
XiaoFei ZhouNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
Ying LiNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
YanJie ShenNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
YuFeng YeNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
ShiHao ChenNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China.
Jia QuNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China. jqu@wmu.edu.cn.ORCID https://orcid.org/0009-0004-2800-6612
QinMei WangNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China. wqm3@mail.eye.ac.cn.ORCID https://orcid.org/0000-0003-0629-0734
Ahmed ElsheikhZhejiang-United Kingdom Joint Laboratory On Ocular Biomechanics, No. 270 Xueyuan West Road, Wenzhou, 325027, Zhejiang, China.
FangJun BaoNational Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, No. 270 Xueyuanxi Road, Wenzhou, 325027, Zhejiang, China. baofjmd@wmu.edu.cn.ORCID https://orcid.org/0000-0001-9881-6267

Funding

Medical Science and Technology Project of Zhejiang Province WKJ-ZJ-2542National Natural Science Foundation of China 82271049
6 · The paper itself

Abstract

backgroundThis retrospective study aimed to evaluate the efficacy of transepithelial accelerated corneal cross-linking (transEpi ACXL) when applied separately or combined with phototherapeutic keratectomy (transPTK ACXL) in keratoconic eyes using biomechanical parameters.

methodsThe study included eyes with progressive keratoconus treated with either continuous transEpi ACXL or transPTK ACXL with 6 months follow-up. The following parameters were assessed preoperatively and 6 months postoperatively: biomechanically corrected intraocular pressure (bIOP), maximum and mean keratometry (K

resultsA total of 75 eyes from 72 patients were included (31 in the transEpi ACXL group and 44 in the transPTK ACXL group). The two groups were comparable in age (23.0 ± 5.0 vs. 21.3 ± 5.2 years) and TKC grade distribution (grades 1-4), with no statistically significant between-group differences (P = 0.321 and 0.766, respectively). Both groups exhibited significant reductions in IIR, and increases in SSIv1 and SSIv2 (all P < 0.05). The improvements in K

conclusionsTransPTK ACXL resulted in better biomechanical and visual benefits in comparison with transEpi ACXL 6 months after treatment. SSIv2 demonstrated superior performance in assessing the efficacy of corneal cross-linking.

Indexed as

BiomechanicsCorneal cross-linkingKeratoconusPhototherapeutic keratectomyTransepithelial

Identifiers

PMID41918137
PMCPMC13041107

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.