Trial reportAlzheimer's research & therapy2026
Effects of 40-Hz transcranial alternating current stimulation on cognition and neural markers in Alzheimer's disease: a randomized, sham-controlled trial.
Trial report in Alzheimer's research & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06565143 (Effect of Transcranial Alternating Current Stimulation), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Transcranial Alternating Current Stimulation(tACS) for Early Alzheimer's Disease
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of transcranial alternating current stimulation on cognitive function in patients with dementia: a systematic review and meta-analysis of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Temporal-Targeted Accelerated 40 Hz tACS Enhances Cognitive Function and Network Integration in Alzheimer's Disease: A Randomized Clinical Trial.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
backgroundAlzheimer’s disease (AD) is characterized by cognitive decline. Gamma-frequency (40 Hz) transcranial alternating current stimulation (tACS) may enhance cognition, although its efficacy and neural mechanisms remain unclear. This study evaluated whether 40-Hz tACS improves cognition in individuals with AD and explored the associated neural correlates using resting-state electroencephalography (rs-EEG) and plasma phosphorylated tau.
methodsIn a randomized, double-blind, sham-controlled trial, 39 participants with AD received either 40-Hz tACS (n = 20) or sham stimulation (n = 19) targeting the left dorsolateral prefrontal cortex (2.0 mA, 30 min/day, 2 weeks). Cognitive and mood outcomes and rs-EEG spectral and connectivity measures were assessed.
resultsCompared with sham, 40-Hz tACS was associated with a trajectory-level signal favoring improved global cognition, reduced depressive symptoms, increased frontal–central theta power, enhanced theta band hippocampal–prefrontal connectivity, stronger low-gamma connectivity at the ROI level, and exploratory reductions in plasma p-tau217 and p-tau181.
conclusionTwo weeks of low-intensity 40-Hz tACS showed target engagement and a trajectory-level cognitive signal in patients with AD. Biomarker changes were exploratory and require confirmation.
trial registrationClinicalTrials.gov NCT06565143 Date: 2024.08.19.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.