Evidence map›Paper›PMID 41917987›Full record

ArticleChild and adolescent psychiatry and mental health2026

Gender differences in a causal model of risk factors underlying early alcohol sipping.

Andrea Maxwell, Kathryn Cullen, Erich Kummerfeld, Rajita Sinha, Anna Zilverstand

Abstract read
In one paragraph

Article in Child and adolescent psychiatry and mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Andrea MaxwellMedical Scientist Training Program, University of Minnesota, Minneapolis, MN, USA.
Kathryn CullenDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, 717 Delaware Street, Minneapolis, MN, 55414, USA.
Erich KummerfeldInstitute for Health Informatics, University of Minnesota, Minneapolis, MN, USA.
Rajita SinhaYale Stress Center, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Anna ZilverstandDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, 717 Delaware Street, Minneapolis, MN, 55414, USA. annaz@umn.edu.ORCID http://orcid.org/0000-0002-4889-9700

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly alcohol sipping with permission, here defined as tasting alcohol without necessarily taking a full drink by late childhood with parental permission, is an early marker of future problematic alcohol use. This study aimed to generate an initial data-driven causal model of the potential risk factors underlying early alcohol sipping and probe gender differences in this model.

methodsWe used deidentified data from the baseline visit of Adolescent Brain and Cognitive Development (ABCD) Study (N = 9,253; 47.2% girls, ages 9-10 years; 76% White, 20% African-American, 8% Other, 7% Asian, 4% Native; 21% Hispanic); 1,266 (13.7%) in this sample endorsed early alcohol sipping by age 9-10 (40.9% girls). We included the top-ranked environmental, health, and psychological factors underlying early alcohol sipping identified among 2000 + variables in a previous study in the same data set. We applied Causal Discovery Analysis to generate combined (boys and girls) and gender-specific causal models to investigate potential causal links with early alcohol sipping. We evaluated model stability by bootstrapping.

resultsFirst, our causal model of early alcohol sipping in both boys and girls suggested that family-level factors directly linked to substance use (i.e., norms around alcohol use and maternal prenatal alcohol use) were causally linked to early alcohol sipping. Second, our causal model of sipping specific to girls suggested that suicidal ideation was causally linked to early alcohol sipping in girls only. Third, our causal model of sipping specific to boys suggested that early alcohol sipping was causally linked to sensation seeking and disliking school in boys only.

conclusionsThe current findings provide an initial model of important risk factors underlying the early onset of alcohol use. More broadly, the results suggest that the mechanisms previously linked to substance use in adolescence and adulthood can be traced back to childhood, and that gender differences are already present at this young age.

Indexed as

AlcoholChildhoodGender differencesSensation seekingSipSuicidal ideation

Identifiers

PMID41917987
PMCPMC13159307

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.