ArticleBMC pediatrics2026
Early postoperative inflammatory markers associated with anastomotic leakage after repair of congenital esophageal atresia.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
purposeEarly clinical signs of anastomotic leakage (AL) after congenital esophageal atresia (EA) repair are often subtle; therefore, adjunctive early indicators are needed.
methodsThis was a single-center retrospective study of a cohort of infants undergoing radical EA repair between 2000–2024. White blood cell count (WBC), C-reactive protein (CRP), and the Noble and Underwood (NUn) score were assessed on postoperative day (POD) 1 and POD2. AL was diagnosed by routine contrast esophagography on POD7–9. Discrimination was evaluated using receiver operating characteristic analysis.
resultsThirty-one infants were included in the study, of which eight (25.8%) developed AL. The WBC count, CRP, and NUn scores on POD1 and POD2 were higher in the AL group (all p < 0.05). On POD1, the WBC count (area under the curve [AUC] 0.853) and NUn score (AUC 0.859) had a sensitivity of 87.5% and negative predictive value of 94.7%. On POD2, the WBC count and NUn score had a specificity of 91.3%.
conclusionInflammatory markers, particularly the WBC count and the NUn score, were associated with AL within 48 h after EA repair and may help rule out AL on POD1 and support suspicion of AL on POD2.
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