Observational studyBMC medical imaging2026
Angio planewave ultrasensitive imaging (Angio PLUS) as an innovative technique in depicting vascularity of median nerve: a prospective observational study.
Observational study in BMC medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundsAssessment of median nerve (MN) microvascularity is critical for early diagnosis of neuropathy, yet conventional techniques like color Doppler flow imaging (CDFI) lack sensitivity for small vessels, while contrast-enhanced ultrasound (CEUS) is invasive. Angio Planewave Ultrasensitive imaging (AP), a novel non-invasive modality, offers high-resolution microvascular visualization, but its application in MN vascularity remains unexplored.
objectivesTo determine the feasibility of Angio Planewave Ultrasensitive imaging (AP) in comparison with color Doppler flow imaging (CDFI) for detection of median nerve (MN) vascularity in healthy volunteers and to explore the correlation between the blood flow distribution of MN on AP and the clinical parameters.
methods30 healthy volunteers were prospectively enrolled in our study. CDFI and AP were performed to evaluate the vascularity of MN in the wrist level and the mid-forearm level. MN vascularity using Adler’s grading on CDFI and AP were compared, and a new classification of vascular distribution was proposed. Two radiologists performed image review for evaluation of intra- and interobserver agreements. The new vascular types in the wrist level and the mid-forearm level were compared. The correlation of clinical parameters and the new vascular types were analyzed.
resultsAP was more sensitive in displaying the vascularity of MN compared with CDFI (p < 0.0001), presenting excellent intra- and inter-observer agreements (k > 0.90) based on the new vascular types. Type I and type II were most frequently detected in the wrist level and the mid-forearm level respectively. There was a weak correlation between the cross-sectional area and vascular distribution at the wrist level and the mid-forearm level (r = 0.290, r = 0.304 respectively, both p < 0.05).
conclusionsAP demonstrated superior sensitivity in visualizing MN vascularity compared to CDFI, with excellent intra- and inter-observer reproducibility using the proposed vascular classification. These findings provide a critical technical foundation for future studies exploring vascular changes in neuropathies and their correlation with clinical outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.