Evidence map›Paper›PMID 41917837›Full record

ArticleBMC infectious diseases2026

Bacteremia complicating urinary tract infections in hospitalized patients in a tertiary care hospital in Palestine, retrospective study.

Razan Nafee, Enas Abu Arrah, Motasem Dweekat, Jamal Qaddumi, Adham Abu Taha, Ali Sabatin, Ayman Dawoud

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Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Razan Nafee *Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine. Razan.Mesleh@hotmail.com.
Enas Abu Arrah *Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Motasem Dweekat *Department of Internal Medicine, An-Najah National University Hospital, Nablus, Palestine.
Jamal Qaddumi *An-Najah National University Faculty of Medicine and Health Sciences, Nablus, Palestine.ORCID https://orcid.org/0000-0001-6984-3020
Adham Abu TahaDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Department of Pathology, An-Najah National University Hospital, Nablus, 44839, Palestine.
Ali SabatinAn Najah National University Hospital (NNUH), Nablus, Palestine.
Ayman DawoudDepartment of Pathology , An-Najah National University Hospital, P.O. Box. 7, Nablus, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBloodstream infections secondary to urinary tract infections (UTIs) are associated with prolonged hospital stays, increased complications, higher costs, and elevated mortality rates. Previous studies reported mortality rates ranging from 25% to 60%. To our knowledge, no studies have yet investigated bloodstream infections secondary to UTIs in Palestine. Therefore, we conducted this study to identify common risk factors associated with bloodstream infections secondary to UTIs, and to describe their clinical progression, outcomes, and mortality.

methodsThis retrospective cross-sectional study was conducted at An-Najah National University Hospital ( ANNUH) and included 140 adult patients aged 19–90 years who had concurrent positive urine and blood cultures for the same pathogen. Demographic, microbiological, and laboratory data were collected from 2018 to 2023. Mortality outcomes were assessed and analyzed in correlation with these findings.

resultsA total of 140 patients were enrolled in the study. Of the isolates, 71.4% were bacterial and 28.6% were fungal. Candida species were the most common isolates (28.6%), followed by Escherichia coli (26.4%). Among the participants, 43% died. Candida bloodstream infection, mechanical ventilation, admission to the intensive care unit, and a history of chronic pulmonary disease were significantly associated with higher mortality. Laboratory parameters including low white blood cell count, hemoglobin, and platelets were also associated with death.

conclusionThis study is the first in Palestine to examine bloodstream infections secondary to UTIs. The findings indicate an epidemiologic shift from predominantly Escherichia coli to Candida species. Mortality was significantly associated with Candida bloodstream infection and risk factors such as intensive care unit admission, mechanical ventilation, and central line use. Ongoing surveillance and periodic monitoring of resistance patterns are essential to improve outcomes and guide empirical therapy. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

BacteremiaUrinary Tract InfectionsAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHospitalizationHumansMaleMiddle AgedMiddle EastRetrospective StudiesRisk FactorsTertiary Care CentersYoung AdultBacteremiaBloodstream infectionsPalestineTertiary care hospitalUrinary tract infections

Identifiers

PMID41917837
PMCPMC13159235

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