Evidence map›Paper›PMID 41917784›Full record

ArticleBrain and behavior2026

Anshen Jieyu Decoction: A Promising Remedy for Depression via AKT/mTOR Pathway Modulation in CUMS Rats.

Zhen Li, Zijun Ji, Zehao Zhang, Xuzhang Wang, Hongyue Yu, Dongrun Yang, Huijin Zhang, Yongsheng Liu, Zhuxin Sui

Abstract read
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In one paragraph

Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Zhen LiUndergraduate Academic Affairs Office, Qilu Medical University, Zibo, China.ORCID https://orcid.org/0009-0008-8828-1033
Zijun JiCollege of Medical Imaging, Qilu Medical University, Zibo, China.ORCID https://orcid.org/0009-0000-2719-1888
Zehao ZhangCollege of Clinical Medicine, Qilu Medical University, Zibo, China.ORCID https://orcid.org/0009-0002-7846-3032
Xuzhang WangCollege of Medical Imaging, Qilu Medical University, Zibo, China.
Hongyue YuCollege of Clinical Medicine, Qilu Medical University, Zibo, China.ORCID https://orcid.org/0009-0004-1460-0709
Dongrun YangCollege of Clinical Medicine, Qilu Medical University, Zibo, China.
Huijin ZhangSchool of Public Health, Qilu Medical University, Zibo, China.
Yongsheng LiuCollege of Clinical Medicine, Qilu Medical University, Zibo, China.
Zhuxin SuiSchool of Basic Medical Sciences, Qilu Medical University, Zibo, China.ORCID https://orcid.org/0009-0008-5989-1705

Funding

school-level Research Project of Qilu College of Medicine JCYXKFFC202508school-level Research Project of Qilu Medical University JCYXKFFC202508
6 · The paper itself

Abstract

objectiveTo investigate the effects of An Shen Jie Yu Tang (ASJYD) on hippocampal morphology, AKT/mTOR phosphorylation, and serum adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels in rats subjected to chronic unpredictable mild stress (CUMS).

methodsThree groups were used: Control, CUMS, and CUMS+ASJYD. Over 30 days, the CUMS and CUMS+ASJYD groups were exposed to stressors. After stress induction and behavioral assessments, the CUMS+ASJYD group received ASJYD for 14 days. Serum ACTH and CORT were quantified by ELISA. Hippocampal p-AKT/p-mTOR protein expression was evaluated by Western blot. Hippocampal neuron morphology was examined via Nissl staining, and mitochondrial ultrastructure via transmission electron microscopy.

resultsCompared to controls, CUMS rats showed reduced sucrose preference, decreased distance/time in the open field center, and increased water maze latency (p<0.01). ASJYD ameliorated these impairments (p<0.01). CUMS rats exhibited elevated ACTH/CORT and decreased p-AKT/p-mTOR (p<0.01). ASJYD reduced ACTH/CORT and increased p-AKT/p-mTOR (p<0.01). Histology revealed CUMS rats had disorganized hippocampal neurons, reduced cell numbers, and nuclear abnormalities, which were improved by ASJYD.

conclusionsASJYD ameliorates CUMS-induced behavioral deficits, reduces hypothalamic-pituitary-adrenal axis hyperactivity, is associated with increased phosphorylation of AKT and mTOR, and protects against hippocampal neuronal damage.

Indexed as

DepressionDrugs, Chinese HerbalProto-Oncogene Proteins c-aktStress, PsychologicalTOR Serine-Threonine KinasesAdrenocorticotropic HormoneAnimalsBehavior, AnimalCorticosteroneDisease Models, AnimalHippocampusMaleNeuronsPhosphorylationRatsRats, Sprague-DawleyAdrenocorticotropic HormoneCorticosteroneDrugs, Chinese HerbalmTOR protein, ratProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesAKT/mTOR signaling pathwayAn Shen Jieyu decoctiondepressionhypothalamic‐pituitary‐adrenal axis (HPA)rat

Identifiers

PMID41917784
PMCPMC13112013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.