Evidence map›Paper›PMID 41917625›Full record

ReviewAdvances in experimental medicine and biology2026

Development of the Cardiovascular System During Adolescence.

Alicia González Represas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Alicia González RepresasDepartment of Functional Biology and Health Sciences, University of Vigo, Vigo, Spain. alicia@uvigo.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transition from childhood to puberty involves profound physiological transformations that significantly impact the cardiovascular system. As biological maturation progresses, mainly driven by hormonal changes, both structural and functional adaptations occur in the heart and blood vessels. The heart increases in size and mass, particularly the left ventricle, allowing for a greater pumping capacity to meet the growing body's metabolic demands. Simultaneously, the vasculature adapts through changes in diameter and elasticity, improving the regulation of blood flow and arterial pressure.Functionally, this stage is marked by a gradual enhancement of cardiovascular efficiency: resting heart rate tends to decrease, stroke volume increases, and autonomic nervous system control becomes more balanced. These changes support improved physical performance. Additionally, sex-specific differences begin to emerge during puberty, reflecting the distinct influence of sex hormones on cardiovascular physiology. Understanding the cardiovascular changes that occur during puberty is essential not only for accurately characterizing normal physiological development but also for identifying early deviations that may be associated with an increased risk of cardiovascular disease later in life.In this context, physical exercise plays a pivotal role. Regular physical activity during childhood and adolescence not only accompanies the biological maturation process but also acts as a key modulator of the hemodynamic, metabolic, and autonomic mechanisms underlying cardiovascular remodeling. Through its influence on variables such as cardiac output, blood pressure, baroreflex sensitivity, endothelial function, and autonomic tone, exercise helps shape a more efficient cardiovascular profile that is better equipped to withstand future physiological and pathological challenges.

Indexed as

Adolescent DevelopmentCardiovascular Physiological PhenomenaCardiovascular SystemPubertyAdolescentAnimalsExerciseFemaleHemodynamicsHumansMaleCardiovascular systemExercisePubertySex

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.