ReviewAdvances in experimental medicine and biology2026
Development of the Muscular and Skeletal System During Adolescence.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Gender- and Age-Related Changes in the Spectrum of the Differentiation Potential of Individual Colonies of Stromal Precursors from Human Bone Marrow.International journal of molecular sciences · 2026Article
- LMS-based continuous reference values for the myokine musclin in serum in children and adults.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The musculoskeletal system undergoes rapid and complex changes during adolescence, driven by mechanical, hormonal, and genetic factors. Among these changes, the development of muscle and the accrual of peak bone mass play a pivotal role in determining long-term physical health and performance capacity. This chapter comprehensively examines the development of muscles, tendons, bones, and joints during this critical life stage, emphasizing key mechanisms such as mechanotransduction, fiber type transitions, and bone remodeling. It explores the interplay of modifiable factors, including physical activity, nutrition, and environmental context, with nonmodifiable determinants such as sex, hormones, and genetics. Particular attention is given to the differential adaptation rates of muscle and tendon, sex-specific injury risks, and the impact of energy availability on tissue development. The chapter integrates recent findings on overuse, underload, and functional adaptations to guide evidence-based strategies aimed at promoting lifelong musculoskeletal health and performance.
Indexed as
Identifiers
41917624What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.