ArticleIndian pediatrics2026
Prognostic Accuracy of Serially Measured Organ Dysfunction Scores in Children with Fluid Refractory Septic Shock.
Article in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo evaluate the prognostic accuracy of serially measured PEdiatric Logistic Organ Dysfunction (PELOD)-2 and pediatric Sequential Organ Failure Assessment (pSOFA) scores for predicting 28-day in-hospital mortality in pediatric fluid-refractory septic shock.
methodsChildren aged < 12 years admitted to the pediatric intensive care unit (PICU) with fluid-refractory septic shock were enrolled. PELOD-2 and age-adapted pSOFA scores were compared using crude and adjusted area under the receiver operating characteristic curve (AUROC) analysis over the first four days of PICU admission.
resultsOf the 93 children analyzed, 38 (40.9%) died, and 45 (48.4%) experienced a PICU length of stay ≥ 7 days. The sensitivity of PELOD-2 (score ≥ 8) to predict 28-day in-hospital mortality increased from 60.5 on day 1 to 84.2% on day 4, whereas that of pSOFA (score ≥ 8) increased from 47.4 to 63.2%. Discriminative power improved over time, with adjusted AUROC for mortality prediction increasing from day 1 to day 4 for both PELOD-2 (0.69 to 0.90) and pSOFA (0.69 to 0.88).
conclusionsIn children with fluid-refractory septic shock, PELOD-2 and pSOFA scores demonstrated increasing prognostic accuracy for 28-day in-hospital mortality when assessed serially, with better discrimination on day 4 compared with baseline scores at admission.
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