ArticleClinical and translational allergy2026
Associations Between Different Eosinophil Activity Markers and Clinical Outcomes in Young Asthmatics.
Article in Clinical and translational allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIdentifying biomarkers for different aspects of asthma morbidity is crucial for effective disease monitoring and management. The performance of fractional exhaled nitric oxide (FeNO), blood eosinophil count (BEC), and eosinophil activity markers should be evaluated.
objectiveThis study aimed to compare the associations of FeNO, BEC, serum and plasma eosinophil-derived neurotoxin (S- and P-EDN), and serum eosinophilic cationic protein (S-ECP) with important clinical outcomes in asthma.
methodsIn total, 390 individuals aged 10-35 years with physician-diagnosed asthma were included. Asthma control test (ACT), spirometry, and methacholine challenge tests were used to assess asthma morbidity. The biomarkers' associations with asthma outcomes: impaired spirometry (FEV
resultsS-EDN had the lowest AIC value of all biomarkers in models assessing the association with reduced lung function, showing better model fit than P-EDN and S-ECP. However, FeNO and BEC had the lowest AIC values for AHR. FeNO was the only biomarker associated with uncontrolled asthma.
conclusionS-EDN may serve as an alternative to BEC in research setting and could be relevant in assessing airway obstruction. However, adding S-EDN as a routine biomarker alongside FeNO and BEC may offer limited additional clinical value. Further research in larger cohorts is needed to validate these findings and establish optimal cut-offs.
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