SynthesisCurrent oncology reports2026
The Influence of Surgical Margins on Oncologic Outcomes in Advanced Laryngeal Cancer: A Systematic Review and Meta-analysis.
Synthesis in Current oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewSurgical margins are a critical factor for oncologic outcomes in head and neck squamous cell carcinoma (SCC), but their significance in advanced laryngeal cancer remains unclear. The objective was to evaluate the impact of surgical margins on survival outcomes in patients undergoing total laryngectomy (TL) for advanced laryngeal SCC.Systematic review and meta-analysis of PubMed, Embase, and Scopus were searched from 1990 to 2025. Eligible studies included randomized clinical trials, prospective, and retrospective cohort studies reporting survival outcomes stratified by surgical margin status in patients undergoing TL. Primary outcome was overall survival (OS). Secondary outcomes included recurrence-free (RFS), disease-free (DFS), and disease-specific survivals (DSS).
methodsPubMed, Embase, and Scopus were searched from 1990 to 2025. Eligible studies included randomized clinical trials, prospective, and retrospective cohort studies reporting survival outcomes stratified by surgical margin status in patients undergoing TL. Primary outcome was overall survival (OS). RECENT
findingsA total of 13 studies (n = 2016 patients) were eligible for quantitative synthesis. In the combined cohort of primary and salvage TL, positive margins were associated with significantly worse OS compared with clear margins (HR, 1.87; p < 0.001). In the salvage-only cohort, the adverse effect was more pronounced (HR, 2.05; p < 0.001). For primary TL, the association was not statistically significant (HR, 1.52; p = 0.07). Positive margins also predicted inferior RFS in primary TL (HR, 1.93; p < 0.001). Close margins were not significantly different from clear margins (HR, 1.28; p = 0.33). Positive surgical margins are associated with significantly worse survival following TL, particularly in salvage cases. Close margins do not appear to confer the same adverse prognostic effect, although trends toward inferior survival were observed. These findings underscore the importance of achieving negative margins whenever feasible, highlight the limitations of current margin definitions in the larynx.
Indexed as
Identifiers
41917505What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.