ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2026
A multivariate prediction model to predict delayed CSF sterilization in paediatric post-meningitic hydrocephalus.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePost-meningitic hydrocephalus (PMH) in children often needs temporary cerebrospinal fluid (CSF) diversion using an Ommaya reservoir. Delayed CSF sterilization remains a critical challenge. This study aimed to develop and validate a multivariate prediction model to estimate the risk of delayed CSF clearance (> 14 days) in pediatric PMH.
methodsA retrospective cohort study was conducted at a tertiary care center between January 2024 and December 2025. Children aged ≤ 12 years with PMH managed via Ommaya reservoir were included. Delayed clearance was defined as more than 14 days to achieve two sterile CSF cultures taken ≥ 48 h apart. Multivariate logistic regression identified independent predictors of delayed CSF clearance. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), Hosmer-Lemeshow test, and overall accuracy.
resultsAmong 37 patients (median age 5 months; 51.4% female), delayed CSF clearance occurred in 24.3% (9/37). Independent predictors included prematurity (OR 6.36; p = 0.008), Acinetobacter infection (OR 5.58; p = 0.013), CSF protein ≥ 300 mg/dL (OR 1.005 per mg/dL; p = 0.038), and age < 5 months (OR 0.89 per month; p = 0.045). The model showed good discrimination (AUC 0.82), calibration (p = 0.36), and accuracy (85%). Because CRP and CSF lactate values were unavailable in the full cohort, exploratory univariate logistic regression was performed in the subset of patients with available data.
conclusionsIn conclusion, we presented a multivariate prediction model as a pilot, internally validated tool designed to estimate the risk of delayed CSF clearance in pediatric post-meningitic hydrocephalus. While the model demonstrated promising predictive accuracy, its findings require confirmation in larger, multicenter prospective studies.
Indexed as
Identifiers
41917470What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.