SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2026
What are the key predictors of visual function recovery in uveitis? A systematic review and meta-analysis unraveling structural, genetic, and immunological determinants.
Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Bridging Preclinical and Clinical Gaps in Ocular Therapeutics: Hydrogel Drug Delivery and 3D Tissue Models.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUveitis represents a heterogeneous inflammatory disorder of the uveal tract that remains a major cause of preventable blindness worldwide. Visual recovery following uveitis is highly variable, influenced by complex interactions between structural, genetic, inflammatory, and therapeutic factors. Understanding these predictors is crucial for optimizing management and prognosis.
objectivesTo identify and synthesize key predictors of visual function recovery in patients with uveitis-associated vision loss through a systematic review and meta-analysis.
methodsA comprehensive search of PubMed, Cochrane Library, Scopus, Web of Science, Embase and ScienceDirect was conducted for studies published between January 2000 and August 2025. Eligible randomized controlled trials and cohort studies evaluating clinical, structural, or genetic predictors of visual recovery were included. Data were analyzed using Comprehensive Meta-Analysis software, with effect sizes expressed as standardized mean differences (SMDs) or odds ratios (ORs). Methodological quality was assessed using the Newcastle-Ottawa Scale and ROBINS-I tool.
resultsFourteen studies met inclusion criteria. Meta-analysis demonstrated a significant overall improvement in best-corrected visual acuity (BCVA; SMD = 0.303; p < 0.001). Retinal structural integrity showed a strong association with visual recovery (SMD = 0.652), and the odds of achieving visual acuity 20/200 or better increased significantly (OR = 2.65; p < 0.001). Genetic polymorphisms in CCR2/CCR5 were associated with visual outcomes, although genetic evidence was limited and requires independent validation; preserved retinal architecture and longer treatment duration were consistently associated with better visual recovery.
conclusionVisual function recovery in uveitis depends on structural preservation, inflammation control, and genetic determinants. Early detection and sustained treatment targeting retinal integrity are essential to prevent irreversible vision loss and enhance patient-specific prognostication.
Indexed as
Identifiers
41917455What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.