Evidence map›Paper›PMID 41917453›Full record

Trial reportScientific reports2026

Neostigmine versus sugammadex on outpatient recovery among obese patients with obstructive sleep apnea: A randomized controlled trial.

Rodney A Gabriel, Brian P Curran, Engy T Said, Paige S Tsuda, Dale N Bongbong, Adam S Deconde, Carol H Yan, Jerry Ingrande

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04570150 (Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04570150 phase4completednot on this map

Optimizing Post-operative Recovery in Bariatric Patients With Obstructive Sleep Apnea Undergoing Outpatient Surgery: A Comparison of Sugammadex and Neostigmine

TypeinterventionalSponsorUniversity of California, San DiegoRan2021 to 2024Enrolled90ConditionsAnesthesiaArmsSugammadex, Neostigmine
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rodney A GabrielDepartment of Anesthesiology, University of California, San Diego, 9400 Campus Point Dr. La Jolla, La Jolla, 92037, CA, USA. ragabriel@health.ucsd.edu.
Brian P CurranDepartment of Anesthesiology, University of California, San Diego, 9400 Campus Point Dr. La Jolla, La Jolla, 92037, CA, USA.
Engy T SaidDepartment of Anesthesiology, University of California, San Diego, 9400 Campus Point Dr. La Jolla, La Jolla, 92037, CA, USA.
Paige S TsudaDepartment of Anesthesiology, University of California, San Diego, 9400 Campus Point Dr. La Jolla, La Jolla, 92037, CA, USA.
Dale N BongbongSchool of Medicine, University of California, San Diego, La Jolla, CA, USA.
Adam S DecondeDepartment of Otolaryngology, University of California, San Diego, La Jolla, CA, USA.
Carol H YanDepartment of Otolaryngology, University of California, San Diego, La Jolla, CA, USA.
Jerry IngrandeDepartment of Anesthesiology, University of California, San Diego, 9400 Campus Point Dr. La Jolla, La Jolla, 92037, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients presenting for outpatient surgery may have several comorbidities, including obesity and obstructive sleep apnea. The objective was to measure the efficacy of sugammadex (versus neostigmine) in reducing post-anesthesia care unit length of stay among obese patients with obstructive sleep apnea undergoing outpatient surgery. Furthermore, we aimed to assess differences in post- and pre-operative pulmonary function test and arterial blood gas metrics. We hypothesized that sugammadex would improve recovery times. This was a single institution randomized controlled double-masked clinical trial assessing the efficacy of sugammadex versus neostigmine in reducing length of stay among obese patients with obstructive sleep apnea undergoing outpatient surgery. Secondary outcomes included changes in pulmonary function test and arterial blood gas measurements postoperatively. Mann Whitney U test was the primary statistic used to compare primary and secondary outcomes. There were 90 subjects enrolled, divided equally into the neostigmine and sugammadex cohorts. The median [quartile] length of stay was 125 min [73, 186] versus 123 min [94, 169] in the neostigmine and sugammadex cohorts, respectively (P = 0.79). There were no statistically significant differences in proportional changes of pulmonary function tests (all P > 0.05) nor arterial blood gas measurements (all P > 0.05). This suggests that among patients with obesity and OSA undergoing low-to-moderate risk surgery in the outpatient setting, routine use of one reversal agent over the other would not affect overall PACU efficiency in an ambulatory surgery center. Trial registration: Clinicaltrials.gov NCT04570150, Principal investigator: Jerry Ingrande, Date of registration: 29/09/2020).

Indexed as

NeostigmineObesitySleep Apnea, ObstructiveSugammadexAdultAmbulatory Surgical ProceduresAnesthesia Recovery PeriodDouble-Blind MethodFemaleHumansLength of StayMaleMiddle AgedRespiratory Function TestsTreatment OutcomeNeostigmineSugammadexNeostigmineObesityObstructive sleep apneaOutpatient surgerySugammadex

Identifiers

PMID41917453
PMCPMC13187052

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.