In one paragraphArticle in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Tamara Viktorovna TyrinovaFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0002-7987-2017 Ludmila Vasilievna SakhnoFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099. lsahno53@mail.ru.ORCID http://orcid.org/0000-0003-3290-7910 Ivan Vladimirovich SavkinFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0002-1065-9234 Ekaterina Jakovlevna ShevelaFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0001-8997-3586 Marina Aleksandrovna TikhonovaFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0002-2366-1667 Anastasiia Yurievna MorenkovaFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0003-0980-1157 Nadezhda Aleksandrovna IlinaFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0002-8633-0662 Oksana Aleksandrovna ChumasovaFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0003-3797-6392 Nadezhda Sergeevna ShkarubaFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0001-7676-6166 Anastasia Valerievna FedorovaResearch Institute of Clinical and Experimental Lymрhology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2, Timakova street, Novosibirsk, Russia, 630060.ORCID http://orcid.org/0009-0004-3285-0568 Yulia Dmitrievna KurochkinaResearch Institute of Clinical and Experimental Lymрhology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2, Timakova street, Novosibirsk, Russia, 630060.ORCID http://orcid.org/0000-0002-7080-777X Vitaly Olegovich OmelchenkoResearch Institute of Clinical and Experimental Lymрhology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2, Timakova street, Novosibirsk, Russia, 630060.ORCID http://orcid.org/0000-0001-6606-7185 Elena Alekseevna LetyaginaResearch Institute of Clinical and Experimental Lymрhology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2, Timakova street, Novosibirsk, Russia, 630060.ORCID http://orcid.org/0000-0002-6275-2924 Maxim Aleksandrovich KorolevResearch Institute of Clinical and Experimental Lymрhology - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 2, Timakova street, Novosibirsk, Russia, 630060.ORCID http://orcid.org/0000-0002-4890-0847 Aleksey Eduardovich SizikovFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0002-7213-7482 Elena Removna ChernykhFederal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya Street, Novosibirsk, Russia, 630099.ORCID http://orcid.org/0000-0003-2346-6279 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Monocytic myeloid-derived suppressor cells (M-MDSCs) expand in axial spondyloarthritis (axSpA), although their pathogenetic role and functional state are still unclear. The aim of this study was to investigate checkpoint receptors PD-1/Tim-3 expression on M-MDSCs in axSpA, assessing their relationship with clinical disease parameters and M-MDSC suppressor potential. The study included 19 healthy donors and 32 axSpA patients. As markers of the suppressor potential of M-MDSCs, suppressor molecules arginase 1 (Arg-1) and tyrosine kinase Mer (MerTK) were evaluated. M-MDSC count and their expression of PD-1, Tim-3, Arg-1, and MerTK were evaluated using flow cytometry. M-MDSC frequency directly correlated with the level of C-reactive protein, whereas PD-1 expression on M-MDSCs inversely correlated with the erythrocyte sedimentation rate. Thus, high axSpA activity was associated with an increased M-MDSC content with unchanged PD-1 expression, whereas low activity was linked to an increased PD-1 expression without changing M-MDSC frequency. Additionally, the PD-1
Indexed as
Axial SpondyloarthritisHepatitis A Virus Cellular Receptor 2Myeloid-Derived Suppressor CellsProgrammed Cell Death 1 ReceptorAdultArginaseC-Reactive ProteinFemaleHumansMaleMiddle AgedArginaseC-Reactive ProteinHAVCR2 protein, humanHepatitis A Virus Cellular Receptor 2PDCD1 protein, humanProgrammed Cell Death 1 ReceptorAxial spondyloarthritisImmune checkpoint receptorsMyeloid-derived suppressor cellsPD-1Tim-3
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