ReviewAdvances in experimental medicine and biology2026
Synthetic Strategies and Immunological Evaluation of C-Linked α-Galactosylceramide Analogs.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 authors.
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Abstract
Invariant natural killer T (iNKT) cells recognize lipid antigens, such as α-galactosylceramide (α-GalCer), presented on CD1d, leading to the production of cytokines. C-Glycoside analogs of α-GalCer have garnered attention due to their stability in vivo and their superior therapeutic effects in disease models, including anti-malarial and anti-tumor activity, compared to native α-GalCer. The carbon linkage of C-glycosides is fundamentally inert to glycosyl hydrolases, but the loss of hydrogen-bonding ability and changes in conformational distribution may influence the biological activity. Recent advancements in the synthesis of C-linked α-GalCer have facilitated the creation of new C-glycoside analogs. This review summarizes the evolution of synthetic strategies and the biological activities of the obtained C-linked α-GalCer analogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.