ReviewAdvances in experimental medicine and biology2026
Chemical Synthesis of Homogeneous Glycoproteins for the Elucidation of Glycan Functions.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
To achieve the synthesis of glycoproteins with homogeneous N-glycans, advanced chemical synthetic methods have been developed. Solid-phase peptide synthesis (SPPS) was optimized specifically for the production of acid-labile glycopeptides. A semisynthetic method for obtaining homogeneous N-glycans has also been developed, involving their isolation from egg yolk. The resulting glycopeptides, along with other peptides, can be coupled in aqueous solution through native chemical ligation (NCL). Furthermore, the final folding of glycoproteins was studied to produce homogeneous glycoproteins. Using these homogeneous glycoproteins, the functions of N-glycans have been evaluated. This review highlights the development of the synthesis of homogeneous glycoproteins and their applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.