Evidence map›Paper›PMID 41917358›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Methods for Studying the Role of ADAMTS13 in Angiogenesis.

Manfai Lee, George M Rodgers

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Manfai LeeDivision of Hematology and Hematologic Malignancies, University of Utah Medical Center, Salt Lake City, UT, USA.
George M RodgersDivision of Hematology and Hematologic Malignancies, University of Utah Medical Center, Salt Lake City, UT, USA. george.rodgers@hsc.utah.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A disintegrin and metalloproteinase with thrombospondin type 1 motifs, member 13 (ADAMTS13), cleaves ultra-large (UL) von Willebrand factor (VWF) multimers released from endothelium, which prevents platelet adhesion and aggregation at the site of vascular injury. Beyond the hemostatic function, ADAMTS13 has also been found to play a role in angiogenesis. We utilized angiogenesis assays to measure the ability of ADAMTS13 to stimulate or inhibit new blood vessel formation. This chapter describes methods for in vitro and organ culture assays used to characterize the angiogenic properties of ADAMTS13 metalloprotease. These methods may be applicable to explore angiogenesis in other soluble proteins.

Indexed as

ADAMTS13 ProteinAngiogenesisNeovascularization, PhysiologicAnimalsCell MovementCell ProliferationChickensChorioallantoic MembraneHumansVascular Endothelial Growth Factor Avon Willebrand FactorADAMTS13 ProteinADAMTS13 protein, humanVascular Endothelial Growth Factor Avon Willebrand FactorADAMTS13AngiogenesisCell migrationCell proliferationChicken chorioallantoic membraneVascular endothelial growth factorVasculogenesis

Identifiers

PMID41917358

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.