ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2026
Heterogeneity in primary gastrointestinal DLBCL: from clinical management to molecular mechanisms and treatment strategies.
Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL), with approximately 30%-40% of cases occurring in extranodal organs. Primary gastrointestinal diffuse large B cell lymphoma (PGI-DLBCL) is a predominant subtype of extranodal lymphoma, accounting for 40%-50% of extranodal DLBCL cases. However, due to its location of onset in the gastrointestinal tract, it is different from cancer of epithelial or primary intranodal DLBCL or other extranodal DLBCL. The patients with PGI-DLBCL are often first diagnosed in the department of gastroenterology and gastrointestinal surgery. These patients are prone to develop bulky masses and lead to severe gastrointestinal complications. The heterogeneity of PGI-DLBCL is not only reflected in the differences in gene mutation profiles and tumor microenvironment but is also closely related to the diversity of clinical manifestations, varied treatment responses, and complex prognostic stratification. Currently, the clinicopathological characteristics and molecular genetics of these patients are not fully understood, which will lead to the clinical management difficulties and challenges. This review provides a relatively comprehensive analysis about the heterogeneity of PGI-DLBCL from four perspectives: aggressive growth features, pathological features, molecular genetic characteristics, and treatments.
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