Evidence map›Paper›PMID 41917327›Full record

ArticleEMBO molecular medicine2026

Bcl-xL blockade targets neutrophils and synergizes with chemotherapy in lung squamous cell carcinoma.

Abdullah Mayet, Beatrice Parma, Déborah Lécuyer, Amaury Defruit, Sarika Rana, Anita Bodac, Pieter Demetter, Sébastien Denanglaire, Abbie S Ireland, Mariana Brandão and 6 more

Abstract read
In one paragraph

Article in EMBO molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Abdullah MayetLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.ORCID 0009-0003-0697-1203
Beatrice ParmaLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.
Déborah LécuyerLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.ORCID 0000-0002-1075-9964
Amaury DefruitLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.ORCID 0009-0003-5512-9936
Sarika RanaLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.
Anita BodacSwiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, 1015, Lausanne, Switzerland.
Pieter DemetterCerba Path, Division CMP, 1070, Bruxelles, Belgium.
Sébastien DenanglaireLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.ORCID 0000-0001-7985-716X
Abbie S IrelandDepartment of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27708, USA.
Mariana BrandãoLung Cancer and Immuno-Oncology Laboratory, Bordet Cancer Research Laboratories, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium.ORCID 0000-0002-1653-3544
Thierry BerghmansThoracic Oncology Functional Unit, Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Faculty of Medicine, Université Libre de Bruxelles, 1070, Bruxelles, Belgium.
Fabienne AndrisLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.ORCID 0000-0002-8644-1020
Stanislas GorielyLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium.
Jean Yannis PerentesDivision of Thoracic Surgery, Department of Surgery, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
Trudy G OliverDepartment of Pharmacology and Cancer Biology, Duke University, Durham, NC, 27708, USA.ORCID 0000-0003-2082-2397
Etienne MeylanLaboratory of Immunobiology, Department of Molecular Biology, Faculty of Sciences, Université Libre de Bruxelles, 6041, Gosselies, Belgium. Meylan.Etienne@chuv.ch.ORCID 0000-0002-0899-2230

Funding

Coordinating center for the NCI small cell lung cancer research consortiumU24CA213274 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Lauren Averett Byers, JOHN D. MINNA · 2017 to 2026
$12.9M
Belgian Cancer Foundation Clinical mandate 2023Belgian Cancer Foundation FA/2022/2020Fonds De La Recherche Scientifique - FNRS (FNRS) CDR J.0162.25Fonds De La Recherche Scientifique - FNRS (FNRS) MISU F.6003.22Fonds De La Recherche Scientifique - FNRS (FNRS) TLV 7.4574.21Fonds De La Recherche Scientifique - FNRS (FNRS) TLV 7.6517.23NIH NCI R01-CA244841-05NIH NCI U24CA213274Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 310030_179324Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 3200-0-239913
6 · The paper itself

Abstract

Tumor-associated neutrophils (TANs) represent a large fraction of immune cells in tumors, but how their regulation and function vary in distinct cancer subtypes remains unknown. In Kras

Indexed as

Antineoplastic Agentsbcl-X ProteinCarcinoma, Squamous CellLung NeoplasmsNeutrophilsAnimalsCarboplatinDisease Models, AnimalHumansMicePaclitaxelAntineoplastic AgentsBcl2l1 protein, mousebcl-X ProteinCarboplatinPaclitaxelBcl-xLLung Squamous Cell CarcinomaMouse Models of Lung CancerTumor-associated Neutrophils

Identifiers

PMID41917327
PMCPMC13179379

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.