Evidence map›Paper›PMID 41917326›Full record

ArticleEMBO molecular medicine2026

JAK1/2 inhibitor ruxolitinib reduces aggregates in cardiac proteinopathy.

Erda Alizoti, Leonie Ewald, Simona Parretta, Jacob J K March, Moritz Meyer-Jens, Ellen Orthey, Christian Conze, Lucie Carrier, Jeffrey Robbins, Sonia R Singh

Abstract read
In one paragraph

Article in EMBO molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Erda AlizotiInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0009-0007-4448-3189
Leonie EwaldInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Simona ParrettaInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0009-0007-8565-2663
Jacob J K MarchInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0009-0002-5495-534X
Moritz Meyer-JensInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-2922-0950
Ellen OrtheyInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christian ConzeTechnology Platform Microscopy and Image Analysis (TP MIA), Leibniz Institute of Virology (LIV), Hamburg, Germany.
Lucie CarrierInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-8776-5820
Jeffrey RobbinsMolecular Cardiovascular Biology, Cincinnati Children's Hospital and Medical Center, Cincinnati, USA.
Sonia R SinghInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.singh@uke.de.ORCID 0000-0002-2996-7333

Funding

Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81X3710111Ernst-und-Berta-Grimmke-Stiftung 6/22Fondation Leducq (Leducq Foundation) 11CVD04Fondation Leducq (Leducq Foundation) 20CVD01
6 · The paper itself

Abstract

Misfolded proteins cause or contribute to a wide range of progressive diseases that are difficult to treat. Desmin-related (cardio-)myopathy (DRM), a well-studied proteinopathy, presents with progressive muscle weakness and shortened life span. Most DRM patients display intracellular accumulation of desmin and its chaperone αB-crystallin (CRYAB). Using an unbiased high-throughput screen, we found that Janus kinase 1 (JAK1) knockdown resulted in lower CRYAB

Indexed as

alpha-Crystallin B ChainDesminJanus Kinase 1Janus Kinase 2PyrazolesAnimalsDisease Models, AnimalHumansMiceMyocytes, CardiacNitrilesPyrimidinesRatsalpha-Crystallin B ChainCryab protein, mouseDesminJanus Kinase 1Janus Kinase 2NitrilesPyrazolesPyrimidinesruxolitinibASB2CRYABDesminJAK1Ruxolitinib

Identifiers

PMID41917326
PMCPMC13179346

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.