Evidence map›Paper›PMID 41917321›Full record

ArticleMedScience2026

Electroacupuncture at ST36 protects against dextran sulfate sodium-induced ulcerative colitis in mice by enhancing sympathetic nerve innervation in colonic tissue.

Dongfeng Zhao, Yuquan Yang, Junhao Liang, Chuanglong Xu, Chunlan Tang, Mingming Zhang, Chenguang Li, Yongjian Zhao, Bing Shu, Wei Gou and 1 more

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In one paragraph

Article in MedScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dongfeng Zhao *Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Yuquan Yang *Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Junhao LiangLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Chuanglong XuNingxia Hui Autonomous Region Hospital of Traditional Chinese Medicine, Yinchuan, 750021, China.
Chunlan TangNingxia Hui Autonomous Region Hospital of Traditional Chinese Medicine, Yinchuan, 750021, China.
Mingming ZhangShanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Chenguang LiLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Yongjian ZhaoLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Bing ShuLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Wei GouDivision of Nephrology and Endocrinology, Naval Medical Center of PLA, Naval Medical University, Shanghai, 200052, China. gouwei1984@163.com.
Yongjun WangLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. yjwang8888@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC), characterized by diffuse colonic inflammation and enteric nervous system (ENS) alterations, remains a therapeutic challenge. While the role of the parasympathetic nervous system in intestinal inflammation has been extensively documented, understanding of sympathetic nervous system (SNS) function in UC pathogenesis remains limited. Electroacupuncture (EA) at ST36 (Zusanli) is a widely used alternative therapy for UC, yet its regulatory effects on the ENS-particularly the SNS-and the underlying mechanisms remain unclear. Here, we established a 2.5% dextran sulfate sodium (DSS)-induced murine UC model and validated disease phenotypes via histological assessment. Using a non-anesthetic EA intervention protocol mimicking the clinical conditions, we found that EA at ST36 attenuated local inflammatory progression in DSS-induced UC mice and mitigated ENS degeneration. Critically, our results demonstrated that EA at ST36 specifically reversed SNS reduction (tyrosine hydroxylase-positive, TH

Indexed as

Acupuncture PointsColitis, UlcerativeColonElectroacupunctureSympathetic Nervous SystemAnimalsDextran SulfateDisease Models, AnimalMaleMiceMice, Inbred C57BLDextran Sulfateanti-inflammationelectroacupunctureST36 (Zusanli)sympathetic nerve systemsulcerative colitis

Identifiers

PMID41917321

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.