Evidence map›Paper›PMID 41917303›Full record

ArticleScientific reports2026

Age-stratified trajectories of patient-reported outcomes and perioperative safety after robot-assisted radical prostatectomy: a prospective multicenter cohort study.

Norihiko Kawamura, Masashi Nakayama, Yusuke Inagaki, Koichi Tsutahara, Koji Hatano, Jiro Nakayama, Yohei Okuda, Yosuke Sekii, Koji Yazawa, Tetsuya Takao and 6 more

Abstract readMulticenter Study
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Norihiko KawamuraDepartment of Urology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Masashi NakayamaDepartment of Urology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Yusuke InagakiDepartment of Urology, Osaka Keisatsu Hospital, Osaka, Japan.
Koichi TsutaharaDepartment of Urology, Osaka General Medical Center, Osaka, Japan.
Koji HatanoDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Jiro NakayamaDepartment of Urology, Osaka Rosai Hospital, Sakai, Japan.
Yohei OkudaDepartment of Urology, Sumitomo Hospital, Osaka, Japan.
Yosuke SekiiDepartment of Urology, Sakai City Medical Center, Sakai, Japan.
Koji YazawaDepartment of Urology, Osaka Keisatsu Hospital, Osaka, Japan.
Tetsuya TakaoDepartment of Urology, Osaka General Medical Center, Osaka, Japan.
Norio NonomuraDepartment of Urology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Masao TsujihataDepartment of Urology, Osaka Rosai Hospital, Sakai, Japan.
Yasushi MiyagawaDepartment of Urology, Sumitomo Hospital, Osaka, Japan.
Hitoshi TakayamaDepartment of Urology, Sakai City Medical Center, Sakai, Japan.
Akira NagaharaDepartment of Urology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Kazuo NishimuraDepartment of Urology, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan. kazuo.nishimura@oici.jp.

Funding

Osaka foundation for the prevention of cancer and cardiovascular diseases S19YK015
6 · The paper itself

Abstract

As life expectancy increases, a growing number of older adults undergo radical prostatectomy for localized prostate cancer; however, longitudinal age-specific functional outcomes remain insufficiently characterized. We conducted a prospective multicenter cohort study evaluating age-stratified trajectories of patient-reported outcomes (PROs) assessed using the Expanded Prostate Cancer Index Composite (EPIC) and perioperative complications following robot-assisted radical prostatectomy (RARP). A total of 604 patients were categorized into three age groups (< 65, 65-74, and ≥ 75 years). PROs were assessed using the EPIC at baseline and at 1, 3, 6, and 12 months postoperatively, and longitudinal changes were analyzed using linear mixed-effects models. Urinary function declined transiently after surgery in all age groups and substantially recovered by 12 months, with no significant differences between men aged ≥ 75 years and younger patients. Sexual function decreased irrespective of age, although younger patients maintained higher absolute scores after nerve-sparing procedures. In contrast, sexual bother demonstrated an age-dependent pattern, with minimal change observed in men aged ≥ 75 years. Perioperative complication rates did not differ significantly across age groups. These findings suggest that chronological age alone should not preclude consideration of RARP in appropriately selected elderly patients and provide evidence supporting individualized surgical decision-making in an aging population.

Indexed as

Patient Reported Outcome MeasuresProstatectomyProstatic NeoplasmsRobotic Surgical ProceduresAgedAge FactorsHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesElderly patientsPatient-reported outcomesProspective cohort studyProstate cancerQuality of lifeRobot-assisted radical prostatectomy

Identifiers

PMID41917303
PMCPMC13181070

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.