Evidence map›Paper›PMID 41917296›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2026

The epigenetic and epitranscriptomic regulation of Brd4-Mettl3 axis on STING mediated vascular calcification.

Junyong Zhao, Xiaolin Luo, Zelan Wang, Wenjian Luo, Shaofa Wu, Xingyu Ma, He Liu, Yang Chen, Shixian Pi, Jiawen Zhang and 4 more

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Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

14 authors.

Junyong Zhao *Department of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xiaolin Luo *Department of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Zelan Wang *Department of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Wenjian LuoDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Shaofa WuDepartment of Nephrology, Youyang Hospital, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xingyu MaDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
He LiuDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Yang ChenDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Shixian PiDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Jiawen ZhangDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Jihang ZhangDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Chuan LiuDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Xianjin BiDepartment of Nephrology, The Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. bixianjin@foxmail.com.
Zhexue QinDepartment of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. zhexueqin@126.com.

Funding

National Key Research and Development Program of China 2022YFA1104204 to C.L.the Chongqing Youth High-End Talent Project to Z.Q.the Natural Science Foundation of Chongqing, China cstc2021jcyj-msxmX0716 to Z.Q.the Xinqiao Hospital of Army Medical University 2022YQB001 to Z.Q.
6 · The paper itself

Abstract

aimsVascular calcification (VC) predicts cardiovascular risk in diabetes, chronic kidney disease (CKD) and atherosclerosis patients and is closely linked to the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs). Our previous work revealed that cGAS-STING signalling pathway in VSMCs increases CKD-associated atherosclerotic plaque vulnerability and recent studies elucidated the involvement of STING in vascular calcification, but its upstream modulation mechanism remains to be elucidated. METHODS AND

resultsDNA damage and robust upregulation of STING occurred in high phosphate (Pi)-stimulated VSMCs, calcified aortic tissues from 1,25(OH)

conclusionsOur study elucidated the interplay between Brd4-mediated epigenetic and Mettl3-dependent epitranscriptomic mechanisms governs STING m6A modification and STING may be a potential therapeutic target for vascular calcification.

Indexed as

Cell Cycle ProteinsMembrane ProteinsMethyltransferasesTranscription FactorsVascular CalcificationAnimalsBromodomain Containing ProteinsCells, CulturedcGAS-STING Signaling PathwayEpigenesis, GeneticEpitranscriptomeHumansMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularBrd4 protein, mouseBromodomain Containing ProteinsCell Cycle ProteinsMembrane ProteinsMethyltransferasesMettl3 protein, mouseNuclear ProteinsPhosphatesSting1 protein, mouseSTING ProteinTranscription FactorsBrd4m6A modificationMettl3STINGVascular calcification

Identifiers

PMID41917296

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.