ArticleTropical animal health and production2026
Development of serum metabolite thresholds for early prediction of single or multiple production diseases in Sahiwal transition cows under tropical conditions.
Article in Tropical animal health and production, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The present study aimed to determine biochemical threshold values for key serum metabolites, including non-esterified fatty acids (NEFA), β-hydroxybutyric acid (BHBA), and glucose and calcium during the prepartum period to establish their predictive potential for production diseases (ketosis, milk fever, mastitis, and metritis) in indigenous Sahiwal cows raised under tropical climates of northern India. A total of 31 Sahiwal cows were monitored from − 6 weeks prepartum to + 7 weeks postpartum, with blood serum sampled at defined intervals (-6, -3, -2, -1 weeks, day of calving, and + 1, +2, + 3, +5, + 7 weeks). Based on the occurrence of production diseases, cows were categorized as healthy with no production disease (NPD; n = 13), single production disease (SPD; n = 11), and multiple production disease (MPD; n = 7). The MPD group exhibited significantly higher (P < 0.05) NEFA and BHBA levels from − 6 weeks and − 3 weeks prepartum, respectively and lower (P < 0.05) glucose and calcium concentrations from − 1 week prepartum onwards compared to SPD and NPD groups. Receiver Operating Characteristic (ROC) curve analysis identified critical thresholds: NEFA ≥ 0.25 mmol/L (-2 weeks) predicted SPD risk, while levels ≥ 0.26 mmol/L (-2 weeks) predicted MPD risk; BHBA ≥ 1.36 mmol/L (calving or week 0) was linked to SPD risk, and levels > 1.28 mmol/L (-2 weeks) indicated MPD risk; glucose ≤ 43.60 mg/dL (calving or week 0) indicated SPD risk, while levels ≤ 38.70 mg/dL (calving or week 0) suggested MPD risk; and calcium ≤ 6.90 mg/dL (calving or week 0) predicted SPD risk, whereas levels ≤ 5.90 mg/dL (calving or week 0) predicted MPD risk. While glucose and calcium thresholds showed high specificity, their low sensitivity underscores the importance of interpreting them in combination with NEFA and BHBA for early disease prediction. In conclusion, these evidence based serum metabolite thresholds provide reliable early predictors of postpartum production diseases in Sahiwal cows, highlighting the importance of routine biochemical monitoring and timely interventions to reduce disease occurrence and enhance herd health and productivity under tropical conditions.
Indexed as
Identifiers
41917270What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.