Evidence map›Paper›PMID 41917235›Full record

SynthesisMolecular genetics and genomics : MGG2026

Investigating the shared genetic architecture between inflammatory bowel disease and pancreatitis: a genome-wide cross-trait analysis.

Hang-Ming Qi, Ting-Ting Liu, Jia-Yun Chen, Ya-Hui Wang, Xiao-Tong Mao, Yuan-Chen Wang, Jing Jin, Xi Lin, Jianfeng Yang, Wen-Bin Zou and 2 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Molecular genetics and genomics : MGG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hang-Ming Qi *Department of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Ting-Ting Liu *Department of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jia-Yun Chen *Department of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Ya-Hui Wang *Department of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Xiao-Tong MaoDepartment of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Yuan-Chen WangDepartment of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jing JinDepartment of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Xi LinDepartment of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Jianfeng YangDepartment of Gastroenterology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, Zhejiang Province, China.
Wen-Bin ZouDepartment of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. dr.wenbinzou@hotmail.com.
Le KangDepartment of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai, China. Kangle_medicine@hotmail.com.
Zhuan LiaoDepartment of Gastroenterology, National Clinical Research Center for Digestive Diseases, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. liaozhuan@smmu.edu.cn.ORCID http://orcid.org/0000-0001-8506-8159

Funding

National Natural Science Foundation of China 82222012National Natural Science Foundation of China 82300642National Natural Science Foundation of China 82330016
6 · The paper itself

Abstract

Epidemiological studies suggested comorbidity between inflammatory bowel disease (IBD) and pancreatitis. However, little is known about their shared genetic architecture. Based on genome-wide association studies (GWAS), we utilized Mendelian randomization (MR) method to investigate the causal relationships between IBD (including ulcerative colitis (UC) and Crohn's disease (CD)) and pancreatitis (including acute pancreatitis (AP) and chronic pancreatitis (CP)). Cross-trait meta-analysis was performed to detect pleiotropic loci between them. The heritability enrichment analysis was conducted to detect their shared disease-associated cell types. TWAS (transcriptome-wide association studies) was used to localize pancreatitis-associated genes in the intestine. MR suggested that UC has a positive causal effect on AP in European populations but CP in East Asian populations. Cross-trait meta-analysis identified 71 SNPs between IBD and pancreatitis. Among those, SNPs within the human Major Histocompatibility Complex (MHC) region are strongly enriched in dendritic cell differentiation pathway. Two SNPs outside of the MHC region were rs1260326 and rs117770045. The proxy SNP of rs117770045 was located on a pancreas exocrine-specific enhancer regulating TRPV6 and also associated with the T cell receptor beta genes. Colocalization analysis revealed that rs1265098 (MHC region) was colocalized among IBD, pancreatitis, and gut microbiota Ruminiclostridium 9. Heritability enrichment demonstrated that IBD and pancreatitis are both associated with dendritic cells. TWAS indicated that SPINK5 in the intestine was associated with pancreatitis. Our findings identify genetic risk-sharing loci and convergent immune pathways linking IBD and pancreatitis.

Indexed as

Inflammatory Bowel DiseasesPancreatitisCrohn DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMajor Histocompatibility ComplexMendelian Randomization AnalysisPolymorphism, Single NucleotideDendritic cellInflammatory bowel diseasePancreatitisPleiotropic

Identifiers

PMID41917235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.