Evidence map›Paper›PMID 41917182›Full record

ArticleCell death and differentiation2026

GBA1 F213I mutation increases the expression of LCN2 promoting neurodegeneration.

Shuxia Wen, Wanqing Xiang, Fei Shen, Nan Jiang, Duan Ma, Jin Zhang

Abstract read
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In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuxia Wen *Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, 200032, Shanghai, China.ORCID http://orcid.org/0009-0009-2208-9628
Wanqing Xiang *Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, 200032, Shanghai, China.
Fei ShenKey Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, 200032, Shanghai, China.
Nan JiangKey Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, 200032, Shanghai, China.
Duan MaKey Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, 200032, Shanghai, China. duanma@fudan.edu.cn.ORCID http://orcid.org/0000-0003-3089-0967
Jin ZhangKey Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, 200032, Shanghai, China. jinzhang@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2393-7897

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81971197
6 · The paper itself

Abstract

GBA1 is the most frequently mutated gene in patients with sporadic Parkinson's disease (PD), and carriers of GBA1 mutations exhibit an earlier age of PD onset and more severe clinical phenotypes. In an MPTP-induced PD model, we observed that Gba1 F213I point mutation mice displayed a more severe dopaminergic neuron loss in substantia nigra pars compacta (SNpc). Combined analysis of gene expression differences in the brain tissues of Gba1

Identifiers

PMID41917182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.