Evidence map›Paper›PMID 41917173›Full record

ReviewDermatologie (Heidelberg, Germany)2026

[Rosai-Dorfman Syndrome-a diverse clinical spectrum].

Annika Firla, Michael Tronnier

Abstract readReviewEnglish Abstract
PubMed Publisher
In one paragraph

Review in Dermatologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Annika FirlaKlinik für Dermatologie, Venerologie und Allergologie, Helios Klinikum Hildesheim, Senator-Braun-Allee 33, 31135, Hildesheim, Deutschland. Annika.firla@helios-gesundheit.de.
Michael TronnierKlinik für Dermatologie, Venerologie und Allergologie, Helios Klinikum Hildesheim, Senator-Braun-Allee 33, 31135, Hildesheim, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rosai-Dorfman syndrome is a rare disease that belongs to the group of non-Langerhans cell histiocytosis. Affected patients can exhibit a wide variety of symptoms, which can be divided into nodal and extranodal manifestations. The syndrome primarily presents with fever, enlarged lymph nodes, and weight loss. Extranodal findings may include pancreatic cysts, hypergammaglobulinemia, and infiltration of testicular tissue. Skin involvement occurs in approximately one-third of cases. In addition to routine beside histopathology, immunohistochemistry with positivity for S100 and CD68 and negativity for CD 1a is particularly decisive for diagnosis. Topical and/or systemic steroids are used as first-line treatment for skin manifestations. In individual case studies, other systemic therapies have been used. Other treatment options include methotrexate (MTX), sirolimus, or rituximab. If KRAS/MAP2K1 mutation is detected, treatment with MEK inhibitors may be considered.

Indexed as

Histiocytosis, SinusDiagnosis, DifferentialHumansImmunosuppressive AgentsMaleSkinImmunosuppressive AgentsFeverHistiocytosisImmunosuppression therapyLymphadenopathyRare diseases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.